Programmable Macromolecule-based RNA-targeting Therapies To Treat Human Neurological Disorders
- ↵* Corresponding author; email: geneyeo{at}ucsd.edu
Abstract
Disruptions in RNA processing play critical roles in the pathogenesis of neurological diseases. In this perspective, we discuss recent progress in the development of RNA-targeting therapeutic modalities. We focus on progress, limitations, and opportunities in a new generation of therapies engineered from RNA binding proteins and other endogenous RNA regulatory macromolecules to treat human neurological disorders.
Keywords
- Received November 15, 2022.
- Accepted January 12, 2023.
- Published by Cold Spring Harbor Laboratory Press for the RNA Society
This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
