INIBIDORES DE SGLT2
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Renal glucose reabsorption inhibitors to treat diabetes
Renal glucose reabsorption inhibitors to treat diabetes
Current therapies to reduce hyperglycaemia in type 2 diabetes mellitus (T2DM) mostly involve insulin-dependent mechanisms and lose their effectiveness as pancreatic β-cell function declines. In the kidney, filtered glucose is reabsorbed mainly via the high-capacity, low-affinity sodium glucose cotransporter-2 (SGLT2) at the luminal surface of cells lining the first segment of the proximal tubules. Selective inhibitors of SGLT2 reduce glucose reabsorption, causing excess glucose to be eliminated in the urine; this decreases plasma glucose.
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2 - Diabetologia
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2 - Diabetologia
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SGLT2 Inhibitors in Type 2 Diabetes Management: Key Evidence and Implications for Clinical Practice - Diabetes Therapy
SGLT2 Inhibitors in Type 2 Diabetes Management: Key Evidence and Implications for Clinical Practice - Diabetes Therapy
SGLT2 Mediates Glucose Reabsorption in the Early Proximal... : Journal of the American Society of Nephrology
SGLT2 Mediates Glucose Reabsorption in the Early Proximal... : Journal of the American Society of Nephrology
Renoprotective Effects of SGLT2 Inhibitors
Renoprotective Effects of SGLT2 Inhibitors
An update on sodium-glucose co-transporter-2 inhibitors for ... : Current Opinion in Endocrinology, Diabetes and Obesity
An update on sodium-glucose co-transporter-2 inhibitors for ... : Current Opinion in Endocrinology, Diabetes and Obesity
Dapagliflozin Binds Specifically to Sodium-Glucose... : Journal of the American Society of Nephrology
Dapagliflozin Binds Specifically to Sodium-Glucose... : Journal of the American Society of Nephrology
SGLT2 Inhibitors and the Risk of Acute Kidney Injury in Older Adults With Type 2 Diabetes
SGLT2 Inhibitors and the Risk of Acute Kidney Injury in Older Adults With Type 2 Diabetes
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