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De Smet Jesuit High School in St. Louis operates the Loyola Academy program, which fully integrates students with Down syndrome into standard academic classes and graduation pathways. The Catholic preparatory school developed specific protocols for mainstreaming students with intellectual disabilities across all educational activities. This integration model, implemented under President Father John Hammond, has influenced curriculum development at other St. Louis institutions including St. Louis University High School. The school's admissions process includes structured campus visit options through fall open houses, daily tours, and shadow day experiences for prospective students. De Smet Jesuit maintains dedicated facilities for both academic instruction and athletic programming on its St. Louis campus. The institution provides comprehensive college preparatory curriculum while preserving traditional Jesuit educational principles. De Smet Jesuit partners with the Hope Haven Foundation to address youth homelessness in the St. Louis region. This collaboration delivers direct support through emergency shelter services and educational assistance. The partnership extends De Smet's community impact beyond its campus through established mentorship frameworks and resource sharing.