@jameemaescience
I’m a neuroscientist and singer/songwriter based out of Nashville, Tennessee.
JAKMIP1, a novel regulator of neuronal translation, modulates synaptic function and autistic-like behaviors in mouse
JAKMIP1, a novel regulator of neuronal translation, modulates synaptic function and autistic-like behaviors in mouse
Autism genetics: searching for specificity and convergence
Autism genetics: searching for specificity and convergence
Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse - Nature Genetics
Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse - Nature Genetics
Human-Specific Transcriptional Regulation of CNS Development Genes by FOXP2
Human-Specific Transcriptional Regulation of CNS Development Genes by FOXP2
The signaling pathways orchestrating both the evolution and development of language in the human brain remain unknown. To date, the transcription factor FOXP2 (forkhead box P2) is the only gene implicated in Mendelian forms of human speech and ...
CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes - PubMed
CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes - PubMed
Overall, this research identifies the behavioral and molecular consequences of <i>CYFIP1</i> overexpression and how they contribute to the variable phenotype seen in Dup15q syndrome and in ASD patients with excess CYFIP1.
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
Identification of the Transcriptional Targets of FOXP2, a Gene Linked to Speech and Language, in Developing Human Brain
Identification of the Transcriptional Targets of FOXP2, a Gene Linked to Speech and Language, in Developing Human Brain
Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the only known cause of developmental speech and language disorders in humans. To date, there are no known targets of human FOXP2 in the nervous system. The ...
Fate of Cajal–Retzius Neurons in the Postnatal Mouse Neocortex
Fate of Cajal–Retzius Neurons in the Postnatal Mouse Neocortex
Cajal–Retzius (CR) neurons play a critical role in cortical neuronal migration, but their exact fate after the completion of neocortical lamination remains a mystery. Histological evidence has been unable to unequivocally determine whether these ...
Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene
Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene
onlinelibrary.wiley.com
onlinelibrary.wiley.com
B1 elements are an abundant class of short interspersed elements (SINEs) in the mouse genome and mobilize by a process known as retrotransposition. Here, we report the characterization of a mutagenic...
Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR
Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR
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