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Accepted for/Published in: JMIR mHealth and uHealth

Date Submitted: Feb 8, 2024
Date Accepted: Mar 11, 2025

The final, peer-reviewed published version of this preprint can be found here:

Promoting Hand Hygiene During the COVID-19 Pandemic: Randomized Controlled Trial of the Optimized Soapp+ App

Baretta D, Rüttimann CL, Amrein MA, Inauen J

Promoting Hand Hygiene During the COVID-19 Pandemic: Randomized Controlled Trial of the Optimized Soapp+ App

JMIR Mhealth Uhealth 2025;13:e57191

DOI: 10.2196/57191

PMID: 40273441

PMCID: 12062755

Promoting hand hygiene during the COVID-19 pandemic: A randomized controlled trial of the optimized Soapp+ app

  • Dario Baretta; 
  • Carole Lynn Rüttimann; 
  • Melanie Alexandra Amrein; 
  • Jennifer Inauen

ABSTRACT

Background:

The adoption of protective behaviors represents a crucial measure to counter the spread of infectious diseases. The development of effective behavior change interventions therefore emerged as public health priority during the COVID-19 pandemic, but randomized controlled trials testing such interventions during the pandemic were scarce. We conducted a Multiphase Optimization Strategy (MOST) to develop, optimize and evaluate a smartphone app, Soapp+, to promote hand hygiene during the COVID-19 pandemic.

Objective:

In this paper, we present the results of the evaluation phase of Soapp+ that tested the app’s efficacy in promoting hand hygiene in comparison to an active control group that used a simplified version of the same app.

Methods:

We conducted a randomized controlled trial from March 2022 to April 2023 involving 193 participants. After baseline, the Soapp+ intervention lasted 32 days, followed by a post-intervention assessment and a 6-month follow-up. The primary outcome was the difference in hand hygiene behavior pre-post, and pre-follow-up. Hand hygiene was assessed with electronic diaries. Group differences were tested intention-to-treat with the Student’s t-test and the non-parametric Wilcoxon Rank Sum test.

Results:

Pre-registered t-tests didn’t show significant differences between groups. Differently, non-parametric analyses evidenced significant group differences in hand hygiene between pre-post and pre-follow-up in favor of the group using the full version of Soapp+.

Conclusions:

Soapp+ was developed through a rigorous experimental method during the ongoing COVID-19 pandemic. The randomized controlled trial provided mixed but encouraging evidence for the efficacy of Soapp+ to promote hand hygiene in the context of a pandemic. Clinical Trial: ClinicalTrials.gov: NCT04830761


 Citation

Please cite as:

Baretta D, Rüttimann CL, Amrein MA, Inauen J

Promoting Hand Hygiene During the COVID-19 Pandemic: Randomized Controlled Trial of the Optimized Soapp+ App

JMIR Mhealth Uhealth 2025;13:e57191

DOI: 10.2196/57191

PMID: 40273441

PMCID: 12062755

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