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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v23i4e25140</article-id>
      <article-id pub-id-type="pmid">33929329</article-id>
      <article-id pub-id-type="doi">10.2196/25140</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>mHealth Interventions for Self-Harm: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Kukafka</surname>
            <given-names>Rita</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Bailey</surname>
            <given-names>Eleanor</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Kleiman</surname>
            <given-names>Evan</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Zima</surname>
            <given-names>Bonnie</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Cliffe</surname>
            <given-names>Bethany</given-names>
          </name>
          <degrees>BSc, MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Department for Health</institution>
            <institution>University of Bath</institution>
            <addr-line>Claverton Down</addr-line>
            <addr-line>Bath, </addr-line>
            <country>United Kingdom</country>
            <phone>44 01225 388388</phone>
            <email>bc731@bath.ac.uk</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0520-3726</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Tingley</surname>
            <given-names>Jessica</given-names>
          </name>
          <degrees>BSc, MSc</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7954-8527</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Greenhalgh</surname>
            <given-names>Isobel</given-names>
          </name>
          <degrees>BSc, MRes</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3537-4072</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Stallard</surname>
            <given-names>Paul</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8046-0784</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department for Health</institution>
        <institution>University of Bath</institution>
        <addr-line>Bath</addr-line>
        <country>United Kingdom</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Child and Adolescent Mental Health Services</institution>
        <institution>Oxford Health NHS Foundation Trust</institution>
        <addr-line>Bristol</addr-line>
        <country>United Kingdom</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Bethany Cliffe <email>bc731@bath.ac.uk</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>4</month>
        <year>2021</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>30</day>
        <month>4</month>
        <year>2021</year>
      </pub-date>
      <volume>23</volume>
      <issue>4</issue>
      <elocation-id>e25140</elocation-id>
      <history>
        <date date-type="received">
          <day>19</day>
          <month>10</month>
          <year>2020</year>
        </date>
        <date date-type="rev-request">
          <day>5</day>
          <month>12</month>
          <year>2020</year>
        </date>
        <date date-type="rev-recd">
          <day>19</day>
          <month>1</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>16</day>
          <month>3</month>
          <year>2021</year>
        </date>
      </history>
      <copyright-statement>©Bethany Cliffe, Jessica Tingley, Isobel Greenhalgh, Paul Stallard. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 30.04.2021.</copyright-statement>
      <copyright-year>2021</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2021/4/e25140" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Self-harm is a growing issue with increasing prevalence rates; however, individuals who self-harm do not often receive treatment. Mobile health (mHealth) interventions are a possible solution to some of the barriers that individuals face when seeking support, and they have also been found to be effective in improving mental health. Thus far, reviews of mHealth interventions for self-harm have been limited by study type. Therefore, we determined that a broader scoping review will provide a more exhaustive understanding of mHealth interventions for self-harm.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This scoping review aims to identify mHealth interventions for self-harm within the literature, understand the types and features of interventions that have been developed and evaluated, highlight research findings around mHealth interventions for self-harm, and determine what outcomes are typically used to assess the efficacy of interventions.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A search was conducted using Embase, PubMed, PsycINFO, PsycEXTRA, Web of Science, and the Cochrane Library. Studies were included if they described an mHealth intervention designed to have a direct (ie, if the intervention was designed for self-harm or for people who self-harm) or indirect (ie, if self-harm was measured as an outcome) treatment effect and if the paper was available in English. There were no exclusion criteria based on the study design.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>A total of 36 papers were included in the review, and most of them were randomized controlled trials published within the last 4 years. The interventions were mostly smartphone apps and calling or texting services, with 62% (21/34) having underlying therapeutic models to inform the intervention content. They were generally shown to be promising and appealing, but only 5 were widely available for use. Outcomes focused on a reduction of self-harm and suicidality, mood, and the users’ experiences of the intervention. Samples were typically nondiverse, and there was limited variety in the study designs and in the measurements of self-harm recovery.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>Promising and appealing mHealth interventions have been developed but are not widely available. Research could benefit from greater diversity as well as a broader and more nuanced understanding of recovery from self-harm.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>mHealth</kwd>
        <kwd>self-harm</kwd>
        <kwd>digital interventions</kwd>
        <kwd>self-injury</kwd>
        <kwd>NSSI</kwd>
        <kwd>mobile phone</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Self-harm</title>
        <p>The National Institute for Health and Care Excellence defines self-harm as any act of self-injury or poisoning, irrespective of the motivation behind the act [<xref ref-type="bibr" rid="ref1">1</xref>]. It is a growing concern that can have great physical, psychological [<xref ref-type="bibr" rid="ref2">2</xref>], and societal [<xref ref-type="bibr" rid="ref3">3</xref>] costs. Notably, self-harm has been identified as a significant and persistent predictor of suicide [<xref ref-type="bibr" rid="ref4">4</xref>]. In recent years, the lifetime prevalence of self-harm in the general English population has seen a sharp increase from 2.4% in 2000 to 6.4% in 2014; this was most common in young adult females who reported an increase in prevalence from 6.5% to 19.7% [<xref ref-type="bibr" rid="ref5">5</xref>]. Furthermore, given that individuals are often reluctant to disclose their self-harm behaviors due to the shame and stigma associated with it [<xref ref-type="bibr" rid="ref6">6</xref>], rates of self-harm may be even higher than what these figures suggest [<xref ref-type="bibr" rid="ref7">7</xref>].</p>
      </sec>
      <sec>
        <title>Help for Self-harm</title>
        <p>Tørmoen et al [<xref ref-type="bibr" rid="ref8">8</xref>] surveyed 11,440 young people aged 14-17 years in Norway and found that only 34% of those who had self-harmed had ever sought professional help, indicating that help-seeking is low among those who self-harm [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. Concerns over being perceived as “attention-seeking” or “crazy” and difficulty talking about their self-harm behaviors have been identified as some of the barriers to seek support by adolescents [<xref ref-type="bibr" rid="ref11">11</xref>]. Furthermore, a lack of effective interventions for self-harm creates barriers to receive support when an individual seeks professional help. The National Institute for Health and Care Excellence guidelines advise against the use of pharmacological treatments for self-harm, instead recommending psychological interventions tailored to self-harm that may involve problem solving, cognitive behavioral or psychodynamic elements [<xref ref-type="bibr" rid="ref12">12</xref>]. Despite this, to date, there is limited high-quality evidence suggesting that psychological or pharmacological interventions for self-harm are effective [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Moreover, increased pressure on services and the resulting difficulties with the availability and accessibility of these interventions can further prevent individuals from receiving support [<xref ref-type="bibr" rid="ref15">15</xref>].</p>
      </sec>
      <sec>
        <title>Use of Mobile Health</title>
        <p>The use of mobile health (mHealth) may help overcome the barriers to treatment accessibility and availability. mHealth is a branch of eHealth, defined by the Global Observatory for eHealth as “medical and public health practice supported by mobile devices, such as mobile phones, patient monitoring devices, personal digital assistants (PDAs), and other wireless devices” [<xref ref-type="bibr" rid="ref16">16</xref>]. Given the ubiquity of mobile phone ownership [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>], providing mental health support in this way has the potential to reach many individuals who may not be receiving help for self-harm. mHealth offers multiple possibilities, including self-help smartphone apps, SMS text messaging with a support service, physical symptom tracking through wearable technologies, and receiving virtual therapy [<xref ref-type="bibr" rid="ref19">19</xref>]. Clough and Casey [<xref ref-type="bibr" rid="ref20">20</xref>] found that mHealth users felt that receiving virtual mHealth therapy was more beneficial compared with face-to-face therapy, particularly highlighting the freedom they felt to be completely open and honest with their therapist. mHealth tools also have merit as standalone interventions, with some studies reporting reductions in symptoms of mental health difficulties, including anxiety [<xref ref-type="bibr" rid="ref21">21</xref>], schizophrenia [<xref ref-type="bibr" rid="ref22">22</xref>], depression [<xref ref-type="bibr" rid="ref23">23</xref>], and borderline personality disorder [<xref ref-type="bibr" rid="ref24">24</xref>].</p>
        <p>Studies investigating the efficacy of mHealth interventions for managing self-harm have also been reviewed but they are limited. Witt et al [<xref ref-type="bibr" rid="ref25">25</xref>] identified only one study that included outcome measures of an mHealth intervention for self-harm, whereas Melia et al [<xref ref-type="bibr" rid="ref26">26</xref>] identified 2. These reviews focused on randomized controlled trials (RCTs) and pre- and poststudies. Arshad et al [<xref ref-type="bibr" rid="ref27">27</xref>] focused more closely on self-harm and identified 22 studies; however, this was still limited by their decision to exclude qualitative studies and those where self-harm was not the primary outcome. A broader scoping review will help to identify more mHealth tools available for managing self-harm and broaden our knowledge of them.</p>
      </sec>
      <sec>
        <title>Aims</title>
        <p>This scoping review aims to (1) identify mHealth interventions for self-harm within the literature, (2) understand the types and features of interventions that have been developed and evaluated, (3) highlight research findings around mHealth interventions for self-harm, and (4) determine what outcomes are typically used to assess the efficacy of interventions.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>A detailed methodology can be found in the review protocol [<xref ref-type="bibr" rid="ref28">28</xref>]. The following databases were searched in April 2020: Embase, PubMed, PsycINFO, PsycEXTRA, Web of Science, and the Cochrane Library. The reference lists of all papers identified in the searches were also screened. <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> describes the full and detailed search strategy.</p>
        <p>After duplicates were removed, the titles and abstracts were initially screened according to the aims of this review and were progressed for a full screening if they met the following inclusion criteria: (1) the study described an mHealth intervention (eg, SMS text messaging, phone calls, or websites accessible through a mobile device) designed to have a direct (ie, if the intervention was designed for self-harm or for people who self-harm) or indirect (if self-harm was measured as an outcome) treatment effect and (2) the paper was in English.</p>
        <p>The full texts of the papers that met these criteria were then screened. Before screening the title and abstract, a pilot screening was performed by all 3 reviewers (BC, JT, and IG) on 20 papers selected at random. An interrated reliability check of at least 75% agreement was required to progress the papers to full screening. Initially, 80% agreement was achieved, and the remaining papers were briefly discussed until 100% agreement was achieved. Each paper was screened by at least two reviewers, with a third reviewer resolving any inconsistencies. During the title and abstract screening, there was 98% agreement between the 2 reviewers on each paper, with the others being discussed and resolved again. The full texts of the progressed papers were screened for eligibility.</p>
      </sec>
      <sec>
        <title>Data Charting Process</title>
        <p>The reviewers extracted predefined data regarding the study details (eg, year and country), participants (eg, number, age, and ethnicity), type of mHealth intervention, study design, measures, and outcomes. Both before and after data extraction, consistency was checked between reviewers using a random sample of papers. Data extraction was an iterative process in which categories were added or amended in accordance with the aims of the review.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Identify mHealth Interventions for Self-Harm Within the Literature</title>
        <p>The search results are summarized in <xref rid="figure1" ref-type="fig">Figure 1</xref>. A total of 295 papers were identified. After duplicates were removed, 78% (229/295) of titles and abstracts were left to be screened. About 35% (79/229) of titles and abstracts progressed to a full-text screening, resulting in 54% (43/79) of papers being excluded. Of these, 51% (22/43) did not present an mHealth intervention for self-harm, 21% (9/43) were systematic reviews that did not identify any papers not already identified by our search, and 19% (8/43) were protocols for studies for which a full text had since become available. Of the remaining 4 papers, 2 (5%) were replies or comments on other studies, 1 (2%) was a content analysis of apps that were commercially available with no references to an evidence base, and 1 (2%) was a description of an app that had already been identified. A total of 36 papers met the inclusion criteria and are summarized in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Flowchart of search results. mHealth: mobile health.</p>
          </caption>
          <graphic xlink:href="jmir_v23i4e25140_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Summary of papers (N=36).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="130"/>
            <col width="120"/>
            <col width="80"/>
            <col width="120"/>
            <col width="100"/>
            <col width="140"/>
            <col width="130"/>
            <col width="100"/>
            <col width="80"/>
            <thead>
              <tr valign="top">
                <td>Intervention details</td>
                <td>Type of intervention</td>
                <td>Design</td>
                <td>Sample</td>
                <td>Type of self-harm</td>
                <td>Self-harm measure used</td>
                <td>Development</td>
                <td>Availability</td>
                <td>Improvement in self-harm</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Rebound (2019) [<xref ref-type="bibr" rid="ref29">29</xref>]: <italic>Accessible anytime</italic><sup>a</sup></td>
                <td>Social network with support from peer workers and clinical psychologists</td>
                <td>RCT<sup>b</sup> (protocol)</td>
                <td> Youth (aged 14-27 years) in recovery from major depressive disorder–Australia</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Risk taking and self-harm inventory</td>
                <td>Collaboration with consumers, youth representatives, and clinicians</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>SIAM (2014) [<xref ref-type="bibr" rid="ref30">30</xref>]: <italic>9 texts sent, staggered for 6 months following A&#38;E<sup>c</sup> discharge</italic></td>
                <td>Supportive and monitoring texts</td>
                <td>RCT (protocol)</td>
                <td>Adults discharged after suicide attempt–France</td>
                <td>Suicidal self-harm</td>
                <td>Columbia-Suicide Severity Rating Scale</td>
                <td>Developed by the authors</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>A Virtual Hope Box (2015; 2017) [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app to help with coping, distraction, relaxation, and positive thinking</td>
                <td>Proof of concept; RCT</td>
                <td>Army veterans at risk of self-harm or suicide–United States</td>
                <td>Suicidal self-harm; suicidal and nonsuicidal self-harm</td>
                <td>Semistructured interview; Beck Scale for Suicidal Ideation and Columbia-Suicide Severity Rating Scale</td>
                <td>Developed by the Department of Defense National Centre for Telehealth and Technology, with feedback from target users</td>
                <td>Free to download</td>
                <td>Yes; no</td>
              </tr>
              <tr valign="top">
                <td>EpxDepression (2017) [<xref ref-type="bibr" rid="ref33">33</xref>]: <italic>Daily EMA<sup>d</sup> for 2-4 months</italic></td>
                <td>Text-based EMA that notifies care team of risk</td>
                <td>Proof of concept</td>
                <td>Adolescents–United States</td>
                <td>Suicidal self-harm</td>
                <td>Last question of PHQ<sup>e</sup>-9</td>
                <td>Clinicians, researchers, and biostatisticians with feedback from target end users</td>
                <td>Available for health care providers on subscription</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Imaginator (2020) [<xref ref-type="bibr" rid="ref34">34</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app to promote self-management</td>
                <td>RCT</td>
                <td>Youth (aged 16-25 years) currently self-harming–United Kingdom</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td> Strength of motivation for reducing self-harm scale, craving experience questionnaire for self-harm, self-harm imagery interview. Self-harm, frequency, severity, and self-efficacy for control were measured with items developed by the enhancer</td>
                <td>Codeveloped with youth with lived experience of self-harm</td>
                <td>Not widely available</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Therapeutic Evaluative Conditioning (2016) [<xref ref-type="bibr" rid="ref35">35</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app to decondition self-harm</td>
                <td>RCT</td>
                <td>Adults with self-harm–international</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Self-injurious thoughts and behaviors interview</td>
                <td>Developed by the authors</td>
                <td>No longer available</td>
                <td>Yes, but did not persist at follow-up</td>
              </tr>
              <tr valign="top">
                <td>BlueIce (2018) [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app to help manage urges to self-harm</td>
                <td>Pre-post phase 1 trial</td>
                <td>Adolescents currently self-harming or at risk of self-harming attending CAMHS<sup>f—</sup>United Kingdom</td>
                <td>Nonsuicidal self-harm</td>
                <td>Semistructured interview; Self Harm data from clinical records</td>
                <td>Coproduced with youth with lived experience of self-harm, with input from clinical staff, academics, and app developers</td>
                <td>Available for CAMHS on subscription</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2018) [<xref ref-type="bibr" rid="ref38">38</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app for mood monitoring and distraction</td>
                <td>Development study</td>
                <td>Aged 18-25 years—Australia</td>
                <td>Nonsuicidal self-harm</td>
                <td>N/A<sup>g</sup></td>
                <td>Designed with target users and clinicians</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>ClinTouch CareLoop enhance management (2014) [<xref ref-type="bibr" rid="ref39">39</xref>]: <italic>Accessible anytime; 44 daily ecological momentary assessment alerts</italic></td>
                <td>Smartphone app for mood monitoring and alerting care team of risk</td>
                <td>RCT (protocol)</td>
                <td>Adults with psychotic disorders—United Kingdom</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Unclear</td>
                <td>Codeveloped with service users, clinicians, academics, and health professionals</td>
                <td>Free to download</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2016) [<xref ref-type="bibr" rid="ref40">40</xref>]: <italic>52 text messages sent twice weekly</italic></td>
                <td>Supportive and informative texts</td>
                <td>Intervention study</td>
                <td>Adults with suicidal ideation—Japan</td>
                <td>Nonsuicidal self-harm</td>
                <td>Researchers developed their own questionnaire measuring the presence of self-harm</td>
                <td>Psychiatry specialists</td>
                <td>Not widely available</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td> A-CHESS (2017) [<xref ref-type="bibr" rid="ref41">41</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app containing safety plan, social network, resources, and interaction dashboard with their therapist</td>
                <td>Qualitative study of experience</td>
                <td> Presented to emergency department following self-harm—Canada</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Last question of PHQ-9, hospital presentations for self-harm</td>
                <td>Developed by the network for improvement of addiction treatment with user feedback from focus groups</td>
                <td>Available for health care providers on subscription</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Safe Storage Intervention (2015) [<xref ref-type="bibr" rid="ref42">42</xref>]: <italic>Texts sent daily</italic></td>
                <td>Social contact via phone conversations and texts</td>
                <td>Cost-effective analysis (protocol)</td>
                <td>Participants recruited to another study–Sri Lanka</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Hospital presentations and coroner’s data</td>
                <td>No data</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Brief mobile treatment [<xref ref-type="bibr" rid="ref43">43</xref>]: <italic>10 staggered phone calls after discharge for 24 weeks; audio messages accessible anytime; text reminders sent weekly</italic></td>
                <td>Phone calls to monitor mood, meditation audio messages, and text reminders of treatment elements</td>
                <td>RCT</td>
                <td>Aged 15-74 years admitted to hospital after self-harm—Sri Lanka</td>
                <td>Suicidal self-harm</td>
                <td>Beck Scale for Suicidal Ideation</td>
                <td>No data</td>
                <td>Not widely available</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>No name (2013) [<xref ref-type="bibr" rid="ref44">44</xref>]: <italic>Staggered texts that start daily and decline gradually to weekly over 3 months</italic></td>
                <td>Supportive text messages</td>
                <td>RCT</td>
                <td>Adults in A&#38;E after self-harm—Ireland</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Unclear—self-harm repetition</td>
                <td>No data</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>No name (2017) [<xref ref-type="bibr" rid="ref45">45</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app to provide care messages, resources, health care contacts, and self-help exercises</td>
                <td>RCT (protocol)</td>
                <td>Adult in A&#38;E after self-harm—Hong Kong</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Hospital presentations and coroner’s data</td>
                <td>No data</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2018) [<xref ref-type="bibr" rid="ref46">46</xref>]: <italic>12-month treatment period, no further detail</italic></td>
                <td>Smartphone app to augment delivery of problem-solving therapy</td>
                <td>RCT (protocol)</td>
                <td>Men in A&#38;E after self-harm–Canada</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Hospital presentations</td>
                <td>No data</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>TeenTEXT (2016) [<xref ref-type="bibr" rid="ref47">47</xref>]: <italic>Receiver sets schedule of when texts will be received</italic></td>
                <td>Supportive texts written by the receiver</td>
                <td>Feasibility study</td>
                <td>Adolescents currently self-harming—United Kingdom</td>
                <td>Nonsuicidal self-harm</td>
                <td>N/A</td>
                <td>Designed with service users with history of self-harm, carers, and clinicians</td>
                <td>Not widely available</td>
                <td>No data (terminated)</td>
              </tr>
              <tr valign="top">
                <td>DBT<sup>h</sup> Coach (2016) [<xref ref-type="bibr" rid="ref48">48</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app that provides coaching in DBT skills</td>
                <td>Pilot</td>
                <td>Individuals seeking DBT—United States</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>SITBI<sup>i</sup>, semistructured interviews</td>
                <td>Involved DBT experts, target end users, and their clinicians</td>
                <td>Available for users on subscription</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2019) [<xref ref-type="bibr" rid="ref49">49</xref>]: <italic>Delivered over 10-12 sessions</italic></td>
                <td>Audio or video calls to deliver problem-solving CBT<sup>j</sup></td>
                <td>RCT</td>
                <td>Aged 16-30 years, depression and self-harm—location unknown</td>
                <td>Nonsuicidal self-harm</td>
                <td>Urgency Perseverance Premeditation Sensation-seeking Impulsive Inventory urgency subscale</td>
                <td>No data</td>
                <td>Not widely available</td>
                <td>No data (terminated)</td>
              </tr>
              <tr valign="top">
                <td>MyPlan (2017) [<xref ref-type="bibr" rid="ref50">50</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app to store safety plan</td>
                <td>RCT (protocol)</td>
                <td>Experiencing self-harm—Denmark</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Self-reported, no further information</td>
                <td>Developed by Skovgaard Larsen et al [<xref ref-type="bibr" rid="ref51">51</xref>]</td>
                <td>Yes (in Denmark and Norway)</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td> SMS SOS (2019) [<xref ref-type="bibr" rid="ref52">52</xref>]: <italic>Staggered texts that start 48 h after discharge from A&#38;E, declining to monthly for 12 months</italic></td>
                <td>Supportive text messages</td>
                <td>RCT (protocol)</td>
                <td>In A&#38;E after self-harm—Australia</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Hospital presentations</td>
                <td>Developed with people with lived experience of self-harm or mental health problems</td>
                <td>Not widely available</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Crisis Text Line (2020) [<xref ref-type="bibr" rid="ref53">53</xref>]: <italic>Accessible anytime</italic></td>
                <td>Texting with a crisis counselor</td>
                <td>Trend analysis</td>
                <td>No criteria—international</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>N/A</td>
                <td>Crisis text line is a global organization</td>
                <td>Available globally</td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>SPARX (2020) [<xref ref-type="bibr" rid="ref54">54</xref>]: <italic>Must complete program within 6 weeks</italic></td>
                <td>Game-style smartphone app</td>
                <td>RCT (protocol)</td>
                <td>Year 8 school students—Australia</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Self-harm questionnaire</td>
                <td>Developed with young people</td>
                <td>Yes (in New Zealand)</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>ERITA (2018) [<xref ref-type="bibr" rid="ref55">55</xref>]: <italic>12 weeks to complete 11 modules</italic></td>
                <td>Website and companion app to receive treatment for emotion regulation</td>
                <td>Pilot</td>
                <td>Adolescents with self-harm—Sweden</td>
                <td>Nonsuicidal self-harm</td>
                <td>Deliberate self-harm inventory</td>
                <td>Developed by the authors</td>
                <td>Not widely available</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>CATCH-IT<sup>k</sup> (2009) [<xref ref-type="bibr" rid="ref56">56</xref>]: <italic>Recipients had 3 phone calls, no further information</italic></td>
                <td>Therapy provided via website with motivational interviewing phone calls</td>
                <td>RCT</td>
                <td>Aged 14-21 years with subthreshold depression—United States</td>
                <td>Nonsuicidal self-harm</td>
                <td>PHQ-A</td>
                <td>Developed by the authors</td>
                <td>Not widely available</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (1999) [<xref ref-type="bibr" rid="ref57">57</xref>]: <italic>Accessible anytime for 6 months following discharge</italic></td>
                <td>Telephone crisis consultation with on-call psychiatrist</td>
                <td>RCT</td>
                <td>Adult inpatients with self-harm—United Kingdom</td>
                <td>Nonsuicidal self-harm</td>
                <td>Hospital presentations</td>
                <td>No data</td>
                <td>Not widely available</td>
                <td>No</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2020) [<xref ref-type="bibr" rid="ref58">58</xref>]: <italic>A module per week for 6 weeks</italic></td>
                <td>Web-based intervention to provide CBT-based modules</td>
                <td>RCT</td>
                <td>Turkish adults with suicidal ideation—United Kingdom and Netherlands</td>
                <td>Suicidal self-harm</td>
                <td>Self-harm questionnaire</td>
                <td>Developed by van Spijker et al [<xref ref-type="bibr" rid="ref59">59</xref>] adapted by the authors</td>
                <td>Not yet, but will be if findings are positive</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2018) [<xref ref-type="bibr" rid="ref60">60</xref>]: <italic>Encouraged to write 5</italic> <italic>min</italic> <italic>a day for 28 days</italic></td>
                <td>Web-based diary</td>
                <td>RCT</td>
                <td>Adults on an online forum who self-harm—international</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>SITBI</td>
                <td>Developed by the author</td>
                <td>Technique can be adopted</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Uncut (2014) [<xref ref-type="bibr" rid="ref61">61</xref>]: <italic>Ecological momentary assessment</italic></td>
                <td>App to track mood and practice DBT skills, therapist can monitor progress</td>
                <td>Development study</td>
                <td>Self-harm experts—Austria, Germany, and United States</td>
                <td>Nonsuicidal self-harm</td>
                <td>N/A</td>
                <td>Developed with international psychological experts</td>
                <td>No data</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Living under control (2017) [<xref ref-type="bibr" rid="ref62">62</xref>]: <italic>A module per week for 6 weeks</italic></td>
                <td>Web-based intervention providing 6 modules around managing thoughts and feelings</td>
                <td>RCT (protocol)</td>
                <td>Adults—Denmark</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Hospital records and self-report questionnaire (no further information)</td>
                <td>Developed by van Spijker et al [<xref ref-type="bibr" rid="ref63">63</xref>] with mental health professionals who work with people experiencing suicidality</td>
                <td>Not yet, but will be if findings are positive</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Crisis Care (2017) [<xref ref-type="bibr" rid="ref64">64</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app containing coping skills, distraction activities, and a help me now section</td>
                <td>Pilot study</td>
                <td>Adolescent psychiatry outpatients—United States</td>
                <td>Suicidal self-harm</td>
                <td>N/A</td>
                <td>Developed by the author</td>
                <td>Not widely available</td>
                <td>Yes</td>
              </tr>
              <tr valign="top">
                <td>Monsenso (2020) [<xref ref-type="bibr" rid="ref65">65</xref>]: <italic>Accessible anytime</italic></td>
                <td>Smartphone app providing DBT skills and mood monitoring; links with clinicians database</td>
                <td>RCT (protocol)</td>
                <td>Adults with borderline personality disorder and self-harm—Denmark</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>Self-harm inventory</td>
                <td>Developed by the author</td>
                <td>Available for health care providers on subscription</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2019) [<xref ref-type="bibr" rid="ref66">66</xref>]: <italic>No details yet</italic></td>
                <td>Supportive text messages</td>
                <td>Development study</td>
                <td>Adolescents with self-harm—China</td>
                <td>Nonsuicidal self-harm</td>
                <td>N/A</td>
                <td>Developed with youth with lived experience of self-harm</td>
                <td>No data</td>
                <td>No data</td>
              </tr>
              <tr valign="top">
                <td>Unnamed (2020) [<xref ref-type="bibr" rid="ref67">67</xref>]: <italic>Unlimited access every evening</italic></td>
                <td>Peer-supported hotline</td>
                <td>Trend analysis</td>
                <td>Teenagers—United States</td>
                <td>Suicidal and nonsuicidal self-harm</td>
                <td>N/A</td>
                <td>Founded by mental health professionals</td>
                <td>Available to teenagers in the United States</td>
                <td>N/A</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>Italics refer to the intervention duration.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>RCT: randomized controlled trial.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>A&#38;E: accident &#38; emergency.</p>
            </fn>
            <fn id="table1fn4">
              <p><sup>d</sup>EMA: ecological momentary assessment.</p>
            </fn>
            <fn id="table1fn5">
              <p><sup>e</sup>PHQ: patient health questionnaire.</p>
            </fn>
            <fn id="table1fn6">
              <p><sup>f</sup>CAMHS: Child and adolescent mental health services.</p>
            </fn>
            <fn id="table1fn7">
              <p><sup>g</sup>N/A: not applicable.</p>
            </fn>
            <fn id="table1fn8">
              <p><sup>h</sup>DBT: dialectical behavior therapy.</p>
            </fn>
            <fn id="table1fn9">
              <p><sup>i</sup>SITBI: self-injurious thoughts and behaviors interview.</p>
            </fn>
            <fn id="table1fn10">
              <p><sup>j</sup>CBT: cognitive behavioral therapy.</p>
            </fn>
            <fn id="table1fn11">
              <p><sup>k</sup>CATCH-IT: Competent Adulthood Transition with Cognitive Behavioural Humanistic and Interpersonal Training.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>The 36 papers related to 35 separate studies, 2 of which were published from the same study with one paper detailing the quantitative findings [<xref ref-type="bibr" rid="ref36">36</xref>] and the other the qualitative findings [<xref ref-type="bibr" rid="ref37">37</xref>]. They were therefore not removed as duplicates; however, as the study details were the same, the study characteristics were merged to not present the same information twice.</p>
        <p>A total of 12 papers reported protocols. The corresponding authors were contacted to request any update or preliminary findings; a preprint paper was received from one, so the protocol was replaced with this and the data were extracted. The remaining 11 protocols had no further data at the time of this review (April-June 2020).</p>
        <p>The most common study design was the RCT (20/35, 57%), with most papers published between 2014 and 2020 (33/35, 94%). Studies were most commonly conducted in Europe (14/35, 40%) and North America (7/35, 20%). Most studies measured self-harm using various self-report questionnaires (18/35, 51%) and looked at both suicidal and nonsuicidal self-harm (19/35, 54%).</p>
        <sec>
          <title>Participants</title>
          <p>The participant data are summarized in <xref ref-type="table" rid="table2">Table 2</xref>. Sample sizes ranged from 3 to 122,909, involving mostly clinical cohorts (24/35, 69%), and approximately half were adult samples (18/35, 51%), with one focusing specifically on young adults (aged 18-25 years). None of the studies included children aged &#60;12 years and adults aged &#62;65 years. Gender was reported in 18 papers, with the majority including more females than males (14/18, 78%); only 1 study included a nonbinary participant (1/18, 6%). Most papers provided no data on ethnicity (25/35, 71%) and those that did recruited mostly White people (8/10, 80%). Presenting problems screened for or required as inclusion criteria among the samples were primarily self-harm (26/35, 74%), depression (22/35, 63%), suicidal ideation (15/35, 43%), and suicide attempts (15/35, 43%).</p>
          <table-wrap position="float" id="table2">
            <label>Table 2</label>
            <caption>
              <p>Participant characteristics (n=35).<sup>a</sup></p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="30"/>
              <col width="470"/>
              <col width="150"/>
              <col width="350"/>
              <thead>
                <tr valign="top">
                  <td colspan="2">Characteristic</td>
                  <td>n (%)</td>
                  <td>Study</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Age (years)</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Adults</td>
                  <td>18 (54)</td>
                  <td>[<xref ref-type="bibr" rid="ref30">30</xref>-<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>-<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Adolescents (up to 18 years)</td>
                  <td>8 (23)</td>
                  <td>[<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Adolescents and adults</td>
                  <td>6 (17)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>No age restriction</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref50">50</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Unknown</td>
                  <td>2 (5)</td>
                  <td>[<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref53">53</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Population</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Clinical</td>
                  <td>24 (69)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Community</td>
                  <td>9 (26)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Clinical and community</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref34">34</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Mental health professionals</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref61">61</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Presenting problems or inclusion criteria</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Self-harm</td>
                  <td>26 (74)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref34">34</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Depression</td>
                  <td>22 (63)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Anxiety</td>
                  <td>13 (37)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Suicidal ideation</td>
                  <td>15(43)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Suicide attempt</td>
                  <td>15 (43)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Borderline personality disorder</td>
                  <td>5 (14)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Psychosis</td>
                  <td>4 (11)</td>
                  <td>[<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Substance or alcohol use</td>
                  <td>4 (11)</td>
                  <td>[<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Eating disorders</td>
                  <td>2 (6)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Sleep disorders</td>
                  <td>2 (6)</td>
                  <td>[<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Neurological disorders</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref32">32</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Somatoform disorder</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref32">32</xref>]</td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table2fn1">
                <p><sup>a</sup>Grist et al (2018) [<xref ref-type="bibr" rid="ref36">36</xref>] and Stallard et al (2018) [<xref ref-type="bibr" rid="ref37">37</xref>] are separate papers from the same study.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
        </sec>
      </sec>
      <sec>
        <title>Understand the Types and Features of Interventions That Have Been Developed and Evaluated</title>
        <sec>
          <title>Characteristics of mHealth Interventions</title>
          <p>Intervention characteristics are summarized in <xref ref-type="table" rid="table3">Table 3</xref> and relate to 34 interventions. As mentioned earlier, another 2 papers reported on different trials of the same intervention. Most studies described apps (15/34, 44%) or texting or calling services (13/34, 38%), and most interventions required a mobile phone (16/34, 47%) or a smartphone (11/34, 32%), whereas the rest required any internet-enabled device (4/34, 12%) or an iPod touch (1/34, 3%). Approximately half of the interventions did not include any face-to-face support (16/34, 47%); of these, 9 were standalone interventions (9/16, 56%), 7 included an element of human support provided digitally (ie, texts from a clinician; 7/16, 21%), and 2 exclusively provided digital support (ie, a hotline; 2/16, 13%). A range of underpinning therapeutic models informing the intervention content were reported, with 21 studies (21/34, 62%) citing at least one approach and cognitive behavioral therapy being the most common (10/34, 29%). Supportive messages or phone calls were the most common elements among the interventions (14/34, 41%). Only 3 (9%) papers specified that the interventions contained a safety plan.</p>
          <table-wrap position="float" id="table3">
            <label>Table 3</label>
            <caption>
              <p>Intervention characteristics (n=34).<sup>a</sup></p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="30"/>
              <col width="470"/>
              <col width="150"/>
              <col width="350"/>
              <thead>
                <tr valign="top">
                  <td colspan="2">Intervention characteristics</td>
                  <td>n (%)</td>
                  <td>Study</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Intervention type</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Apps</td>
                  <td>15 (44)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Texting or calling services</td>
                  <td>13 (38)</td>
                  <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Websites or web-based therapies</td>
                  <td>4 (12)</td>
                  <td>[<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Web-based diary</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref60">60</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Social network</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Device</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Mobile phone</td>
                  <td>16 (47)</td>
                  <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Smartphone</td>
                  <td>11 (32)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Any internet-enabled device</td>
                  <td>4 (12)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>iPod touch (or iPhone)</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref48">48</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Human support included</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Face-to-face provided</td>
                  <td>12 (35)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>-<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Digital support provided</td>
                  <td>7 (21)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>No support</td>
                  <td>9 (27)</td>
                  <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Both compared</td>
                  <td>2 (6)</td>
                  <td>[<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Not specified</td>
                  <td>4 (12)</td>
                  <td>[<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref61">61</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Underpinning therapeutic model</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Cognitive behavioral therapy</td>
                  <td>10 (29)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Dialectical behavior therapy</td>
                  <td>6 (18)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Cognitive</td>
                  <td>3 (9)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Behavioral</td>
                  <td>3 (9)</td>
                  <td>[<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Mindfulness</td>
                  <td>2 (6)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Problem-solving therapy</td>
                  <td>2 (6)</td>
                  <td>[<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Acceptance and commitment therapy</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Interpersonal psychotherapy</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Autobiographic self enhancement</td>
                  <td>1 (3)</td>
                  <td>[<xref ref-type="bibr" rid="ref60">60</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Not specified</td>
                  <td>13 (38)</td>
                  <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="4">
                    <bold>Features</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Supportive messages or phone calls</td>
                  <td>14 (41)</td>
                  <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Coping skills</td>
                  <td>9 (27)</td>
                  <td>[<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Mood diaries</td>
                  <td>8 (24)</td>
                  <td>[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Links to helplines, services, or caregivers</td>
                  <td>8 (24)</td>
                  <td>[<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>-<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Problem-solving techniques</td>
                  <td>6 (18)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Alerts to clinicians</td>
                  <td>6 (18)</td>
                  <td>[<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Mood lifting or physical activities</td>
                  <td>6 (18)</td>
                  <td>[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Information and psychoeducation</td>
                  <td>5 (15)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Relaxation and meditation</td>
                  <td>5 (15)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Mindfulness</td>
                  <td>5 (15)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Thought challenging</td>
                  <td>5 (15)</td>
                  <td>[<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Photos, music, and other media</td>
                  <td>4 (12)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Medication and intervention reminders</td>
                  <td>4 (12)</td>
                  <td>[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Social and peer support</td>
                  <td>3 (9)</td>
                  <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Safety plan</td>
                  <td>3 (9)</td>
                  <td>[<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Distraction methods</td>
                  <td>3 (9)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Games</td>
                  <td>3 (9)</td>
                  <td>[<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table3fn1">
                <p><sup>a</sup>Bush et al (2015) [<xref ref-type="bibr" rid="ref31">31</xref>] and Bush et al (2017) [<xref ref-type="bibr" rid="ref32">32</xref>] relate to the same intervention; Grist et al (2018) [<xref ref-type="bibr" rid="ref36">36</xref>] and Stallard et al (2018) [<xref ref-type="bibr" rid="ref37">37</xref>] are separate papers from the same study.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
        </sec>
        <sec>
          <title>Development and Availability</title>
          <p>Half of the mHealth interventions were developed with multiple collaborators (17/34, 50%), including mental health professionals (10/34, 29%), target end users (11/34, 32%), and companies or organizations (3/34, 9%). Most interventions were not currently available to the public (20/34, 59%). Conversely, only 15% (5/34) are publicly available, whereas others are available for purchase by health care professionals or services (4/34, 12%) or users (1/34, 3%). <xref ref-type="table" rid="table1">Table 1</xref> provides further details on the intervention development and availability.</p>
        </sec>
      </sec>
      <sec>
        <title>Highlight Research Findings Around mHealth Interventions for Self-Harm</title>
        <sec>
          <title>Study Findings</title>
          <p>Of the 19 papers that reported outcomes, 14 (74%) reported positive findings postintervention. Of the 5 studies that did not report positive findings, 2 (26%) were terminated during recruitment due to a lack of feasibility. One study noted that this was due to high levels of depression and the reluctance of participants who self-harmed to engage with mental health services [<xref ref-type="bibr" rid="ref49">49</xref>], whereas the other suggested it was a good intervention but Child and Adolescent Mental Health Services was the wrong setting due to clinicians’ time constraints [<xref ref-type="bibr" rid="ref47">47</xref>]. Furthermore, 3 studies reported no significant effect of the intervention on self-harm recovery [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref57">57</xref>], one of which cited past episodes of self-harm as a barrier to efficacy [<xref ref-type="bibr" rid="ref57">57</xref>].</p>
          <p>Clinician and parental attitudes were typically favorable toward the interventions [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], with only 2 papers reporting concerns [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. The identified benefits include promoting self-efficacy [<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref58">58</xref>], helping difficult disclosure [<xref ref-type="bibr" rid="ref33">33</xref>], immediate access [<xref ref-type="bibr" rid="ref43">43</xref>], time and cost benefits [<xref ref-type="bibr" rid="ref55">55</xref>], encouraging help-seeking [<xref ref-type="bibr" rid="ref40">40</xref>], being useful in crises [<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>], and having a positive influence on the therapeutic alliance in the face-to-face element within blended approaches [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. Barriers were not commonly mentioned in the papers, although 2 papers did note that digital interventions that were administered by a mental health worker posed challenges due to the lack of engagement with mental health services among people who self-harm [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Determine What Outcomes Are Typically Used to Assess the Efficacy of Interventions</title>
        <p>The study outcomes are summarized in <xref ref-type="table" rid="table4">Table 4</xref>. Most studies had multiple outcomes related to self-harm (21/35, 60%), suicide attempts (19/35, 54%), suicidal ideation (16/35, 46%), intervention experience (16/35, 46%), and engagement with the intervention (13/35, 37%). Other mental health issues such as depression (16/35, 46%) and anxiety (9/35, 26%) were also considered. Outcomes related to self-harm mostly focused on episode frequency (14/21, 67%), whereas others focused on repeated presentations to hospital (5/21, 24%) or self-harm thoughts or urges (4/21, 19%).</p>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Study outcomes (n=35).<sup>a</sup></p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="470"/>
            <col width="150"/>
            <col width="350"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Outcome</td>
                <td>n (%)</td>
                <td>Study</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="4">
                  <bold>Mental health</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>SH<sup>b</sup> frequency</td>
                <td>14 (40)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref34">34</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Presentations to hospital for SH</td>
                <td>5 (14)</td>
                <td>[<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>SH thoughts or urges</td>
                <td>4 (11)</td>
                <td>[<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>SH (specifics unclear)</td>
                <td>2 (6)</td>
                <td>[<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Suicidal ideation</td>
                <td>16 (46)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Suicide attempts</td>
                <td>19 (54)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Depression</td>
                <td>16 (46)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Anxiety</td>
                <td>9 (26)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Eating disorders</td>
                <td>3 (9)</td>
                <td>[<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Borderline personality disorder</td>
                <td>2 (6)</td>
                <td>[<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Psychosis</td>
                <td>1 (3)</td>
                <td>[<xref ref-type="bibr" rid="ref54">54</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Other well-being</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Other mental well-being</td>
                <td>7 (20)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>-<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Interpersonal issues</td>
                <td>7 (20)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Hopelessness</td>
                <td>6 (17)</td>
                <td>[<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Sleep</td>
                <td>3 (9)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Alcohol or substance use</td>
                <td>3 (9)</td>
                <td>[<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Quality of life</td>
                <td>3 (9)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref62">62</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Other self-destructive behaviors</td>
                <td>2 (6)</td>
                <td>[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Intervention feasibility and acceptability</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Experience</td>
                <td>16 (46)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref66">66</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Engagement</td>
                <td>13 (37)</td>
                <td>[<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Health care costs</td>
                <td>1 (3)</td>
                <td>[<xref ref-type="bibr" rid="ref46">46</xref>]</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>Grist et al (2018) [<xref ref-type="bibr" rid="ref36">36</xref>] and Stallard et al (2018) [<xref ref-type="bibr" rid="ref37">37</xref>] are separate papers from the same study.</p>
            </fn>
            <fn id="table4fn2">
              <p><sup>b</sup>SH: self-harm.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This scoping review identified 36 papers relating to 34 separate mHealth tools for managing self-harm. Papers were primarily RCTs and protocols published in Europe or North America within the last 6 years. This recent increase in papers reflects the growing interest in developing evidence-based mHealth interventions to improve access to psychological therapies. The large number of protocols suggests that this trend will continue as more findings are published in the coming years. Participants were mostly White adult females recruited from clinical populations, with only one nonbinary participant across all the studies, and many did not report the ethnicity of their participants. This is concerning given the high prevalence of self-harm found in both ethnic [<xref ref-type="bibr" rid="ref68">68</xref>] and gender minorities [<xref ref-type="bibr" rid="ref69">69</xref>]. It is possible that other nonbinary or gender-diverse individuals participated in these studies, but they were not truly represented in the way that the researchers assessed or reported participant demographics.</p>
        <p>Depression and anxiety were the 2 most highly studied comorbidities, which is consistent with research suggesting strong correlations between these disorders and self-harm [<xref ref-type="bibr" rid="ref70">70</xref>]. The interventions most commonly studied were not blended with any face-to-face support and were mostly text or call-based services or apps used on mobile phones or smartphones. Considering the ubiquity of both mobile phones [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref71">71</xref>] and smartphones [<xref ref-type="bibr" rid="ref71">71</xref>], this is a positive finding and suggests that there are indeed mHealth interventions that could be more widely accessed. Interestingly, no interventions designed for use on other devices, such as wearable technologies, have been identified. This is despite research suggesting that they are acceptable for treating mental health issues among those who do not typically engage with mental health services [<xref ref-type="bibr" rid="ref72">72</xref>]. However, this is still a relatively new area, and wearable devices designed to treat or help manage mental health difficulties are predicted to increase over the next few years [<xref ref-type="bibr" rid="ref73">73</xref>].</p>
        <p>Several studies did not specify any underpinning therapeutic models informing the content of their intervention, which raises concerns given the unhelpful and even dangerous advice that has been found in other freely available mental health apps [<xref ref-type="bibr" rid="ref74">74</xref>]. Similarly, less than a third of the interventions were developed with individuals who have lived experience of self-harm, despite evidence suggesting that this could lead to more effective interventions being developed. Given the expertise of those with lived experience of self-harm, their input is essential [<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref76">76</xref>].</p>
        <p>Most studies testing interventions reported overall promising findings, suggesting that mHealth can be a viable tool for people struggling with self-harm. The study outcomes largely promoted a reduction in self-harm frequency over and above others, such as a reduction in self-harm urges or severity. Although reduced frequency is a common measure of self-harm recovery within research, it has been argued that it is not advisable to rely solely on this; a reduction in self-harm episodes may mean that each episode has become more severe or has been replaced with a different type of self-destructive behavior [<xref ref-type="bibr" rid="ref77">77</xref>]. Overall, there needs to be a more consistent framework to assess outcomes from self-harm research, with further research looking into the maintenance of positive outcomes. Similarly, there was considerable variation in the tools used to measure self-harm across the studies. This makes comparisons between studies difficult; therefore, greater consistency may also be beneficial.</p>
        <p>Another commonly observed finding was the clinicians’ favorable attitudes toward the intervention. This reflects overall positive attitudes and an eagerness to incorporate technology into practice found in research on clinicians’ attitudes toward technology in mental health care [<xref ref-type="bibr" rid="ref78">78</xref>]. This is important considering that there is research highlighting that clinicians’ attitudes are pivotal in intervention implementation [<xref ref-type="bibr" rid="ref79">79</xref>].</p>
        <p>A barrier to the implementation of blended interventions that required clinician involvement was the lack of engagement that people who self-harm have with mental health services. This is consistent with the body of literature that corroborates the lack of professional help-seeking among people who self-harm [<xref ref-type="bibr" rid="ref8">8</xref>-<xref ref-type="bibr" rid="ref11">11</xref>] and further emphasizes the need for mHealth interventions for self-harm that individuals can access easily and discretely. Despite many studies having positive outcomes, it seems that not many of the interventions studied are readily available to the general public or even to those attending mental health services. Moreover, few papers made this information apparent, so information on availability was sought from internet and app store searches and by contacting the authors of the papers.</p>
      </sec>
      <sec>
        <title>Implications for Future Research</title>
        <p>This review identified several limitations in the current literature on mHealth tools for managing self-harm. Notably, research thus far has been limited to White adult females from western societies, yet self-harm has been identified as a significant issue among minority groups [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], highlighting the need to diversify research by recruiting understudied groups such as males and minority populations who may also benefit from mHealth interventions. It is also important for future studies to report the ethnicity of participants. Similarly, participants have mostly been from clinical samples; however, given that people who self-harm do not often seek professional help, it is possible that findings from clinical samples may not necessarily be generalizable to wider populations who self-harm. Therefore, it is important to assess the efficacy of interventions in community samples. It is also essential for more intervention developers to collaborate with people who have lived experience of self-harm, given the limited instances thus far highlighted in this review.</p>
        <p>Another notable point is that the measurements of self-harm recovery were typically restricted to a reduction in the frequency of episodes and, although this may be a useful assessment, it may also be worth considering measuring other elements as well, such as the severity of self-harming episodes or any other substitute self-destructive behaviors.</p>
        <p>Another consideration to take forward from this review is the reliance on RCTs to evaluate digital interventions. Although RCTs have long been considered the gold standard method, the pace at which digital interventions develop and evolve means that the data can be outdated before the trial has been completed [<xref ref-type="bibr" rid="ref80">80</xref>-<xref ref-type="bibr" rid="ref82">82</xref>]. Following this, it may be prudent for future research to also consider different study designs, such as pre- and posttests that can keep up with the rapid development of digital interventions. Furthermore, RCTs can indicate whether an intervention is effective but may be limited in their ability to explore the reason [<xref ref-type="bibr" rid="ref83">83</xref>]. Therefore, it may also be beneficial for future research to apply the NIMH’s experimental therapeutics approach or use qualitative studies that can contribute further to the understanding of how and why certain interventions are effective as well as whether they are safe and do no harm. Similarly, the application of the experimental therapeutic approach may contribute further to the understanding of how and why certain interventions are effective [<xref ref-type="bibr" rid="ref84">84</xref>]. Future work should also focus on the implementation and dissemination of effective interventions, following the lack of availability of interventions within the papers in this review.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>As the purpose of this review was to collate the data available on mHealth tools for managing self-harm, there was no scope to conduct a quality assessment of the included studies. This means that we cannot verify that the research included here is of sufficient quality to draw concrete inferences from. This review may also have been limited by the decision to not include any papers for which there was no English version available. Nonetheless, this review offers insight into the current evidence base for mHealth interventions for self-harm.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This review has synthesized the current evidence for mHealth tools for managing self-harm. Overall, there are useful interventions that have been developed to promote recovery from self-harm. However, certain limitations pose challenges in drawing firm conclusions from the included studies. Suggestions for how future research can improve upon this have been made, in the hope of developing a robust evidence base so that clinicians and users are better equipped to make informed decisions about which mHealth tools to use. This will hopefully help to overcome some of the barriers that people who self-harm face in accessing support.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Full search strategy.</p>
        <media xlink:href="jmir_v23i4e25140_app1.doc" xlink:title="DOC File , 28 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">RCT</term>
          <def>
            <p>randomized controlled trial</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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