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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR</journal-id>
      <journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id>
      <journal-title>Journal of Medical Internet Research</journal-title>
      <issn pub-type="epub">1438-8871</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v24i8e37952</article-id>
      <article-id pub-id-type="pmid">35925651</article-id>
      <article-id pub-id-type="doi">10.2196/37952</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Digital Patient Experience: Umbrella Systematic Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Leung</surname>
            <given-names>Tiffany</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Mehdizadeh</surname>
            <given-names>Hamed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Veldandi</surname>
            <given-names>Hareesh</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Calisto</surname>
            <given-names>Francisco Maria</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Wang</surname>
            <given-names>Tingting</given-names>
          </name>
          <degrees>MA</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Industrial Design Engineering</institution>
            <institution>Delft University of Technology</institution>
            <addr-line>Gebouw 32</addr-line>
            <addr-line>Landbergstraat 15</addr-line>
            <addr-line>Delft, 2628 CE</addr-line>
            <country>Netherlands</country>
            <phone>31 623018218</phone>
            <email>t.wang-8@tudelft.nl</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1031-6346</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Giunti</surname>
            <given-names>Guido</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0836-9825</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Melles</surname>
            <given-names>Marijke</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6342-6493</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Goossens</surname>
            <given-names>Richard</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8304-3916</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Industrial Design Engineering</institution>
        <institution>Delft University of Technology</institution>
        <addr-line>Delft</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Digital Health Design and Development</institution>
        <institution>University of Oulu</institution>
        <addr-line>Oulu</addr-line>
        <country>Finland</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Tingting Wang <email>t.wang-8@tudelft.nl</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>8</month>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>4</day>
        <month>8</month>
        <year>2022</year>
      </pub-date>
      <volume>24</volume>
      <issue>8</issue>
      <elocation-id>e37952</elocation-id>
      <history>
        <date date-type="received">
          <day>17</day>
          <month>3</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>15</day>
          <month>5</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>26</day>
          <month>5</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>31</day>
          <month>5</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Tingting Wang, Guido Giunti, Marijke Melles, Richard Goossens. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 04.08.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://www.jmir.org/2022/8/e37952" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The adoption and use of technology have significantly changed health care delivery. Patient experience has become a significant factor in the entire spectrum of patient-centered health care delivery. Digital health facilitates further improvement and empowerment of patient experiences. Therefore, the design of digital health is served by insights into the barriers to and facilitators of digital patient experience (PEx).</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aimed to systematically review the influencing factors and design considerations of PEx in digital health from the literature and generate design guidelines for further improvement of PEx in digital health.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>We performed an umbrella systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology. We searched Scopus, PubMed, and Web of Science databases. Two rounds of small random sampling (20%) were independently reviewed by 2 reviewers who evaluated the eligibility of the articles against the selection criteria. Two-round interrater reliability was assessed using the Fleiss-Cohen coefficient (<italic>k</italic>1=0.88 and <italic>k</italic>2=0.80). Thematic analysis was applied to analyze the extracted data based on a small set of a priori categories.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The search yielded 173 records, of which 45 (26%) were selected for data analysis. Findings and conclusions showed a great diversity; most studies presented a set of themes (19/45, 42%) or descriptive information only (16/45, 36%). The digital PEx–related influencing factors were classified into 9 categories: patient capability, patient opportunity, patient motivation, intervention technology, intervention functionality, intervention interaction design, organizational environment, physical environment, and social environment. These can have three types of impacts: positive, negative, or double edged. We captured 4 design constructs (personalization, information, navigation, and visualization) and 3 design methods (human-centered or user-centered design, co-design or participatory design, and inclusive design) as design considerations.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>We propose the following definition for digital PEx: “Digital patient experience is the sum of all interactions affected by a patient’s behavioral determinants, framed by digital technologies, and shaped by organizational culture, that influence patient perceptions across the continuum of care channeling digital health.” In this study, we constructed a design and evaluation framework that contains 4 phases—define design, define evaluation, design ideation, and design evaluation—and 9 design guidelines to help digital health designers and developers address digital PEx throughout the entire design process. Finally, our review suggests 6 directions for future digital PEx–related research.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>digital health</kwd>
        <kwd>eHealth</kwd>
        <kwd>telemedicine</kwd>
        <kwd>telehealth</kwd>
        <kwd>mobile health</kwd>
        <kwd>mHealth</kwd>
        <kwd>patient experience</kwd>
        <kwd>user experience</kwd>
        <kwd>influencing factors</kwd>
        <kwd>user-centered design</kwd>
        <kwd>human-computer interaction</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Recently, there has been a significant increase in the use of digital health technologies. In addition, many countries currently use digital health technologies to support health care service delivery to overcome the disruptions caused by the COVID-19 pandemic. These include web-based patient consultations and requesting pharmacy and medication refills [<xref ref-type="bibr" rid="ref1">1</xref>]. Digital health offers care without the risk of exposure to the virus, especially for vulnerable patients such as older adults and patients with chronic diseases [<xref ref-type="bibr" rid="ref2">2</xref>]. Before the COVID-19 pandemic, there was increasing recognition of the potential of digital health to improve the accessibility of health care in different clinical settings (eg, ambulatory care, acute care, and inpatient care) [<xref ref-type="bibr" rid="ref3">3</xref>]. Digital health provides an opportunity to both reduce the costs of care and improve patient affordability [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>], and previous research suggests that digital health has the potential to provide health prevention, consultation, treatment, and management [<xref ref-type="bibr" rid="ref5">5</xref>-<xref ref-type="bibr" rid="ref10">10</xref>]. With digital health solutions continuing to grow in both number and functionality, patient interest in digital health has rapidly increased, leading to an expanding reliance on digital health technologies [<xref ref-type="bibr" rid="ref11">11</xref>].</p>
        <p>As digital health has become a more familiar term, it has generated many definitions, and the concept has been expanded to encompass a much broader set of scientific concepts and technologies [<xref ref-type="bibr" rid="ref12">12</xref>]. These include digital health applications, ecosystems and platforms [<xref ref-type="bibr" rid="ref13">13</xref>], patient portals [<xref ref-type="bibr" rid="ref14">14</xref>], mobile health apps [<xref ref-type="bibr" rid="ref15">15</xref>], eHealth records, and appointment scheduling applications [<xref ref-type="bibr" rid="ref16">16</xref>]. For the purposes of this study, we will use eHealth, mobile health, telemedicine, telehealth, virtual health, remote health, electronic consultations, and health information systems (HISs) as interchangeable terms for digital health.</p>
      </sec>
      <sec>
        <title>Patient Experience in Digital Health</title>
        <p>Digital health has the potential to improve patients’ overall health care experience [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref19">19</xref>]. However, there is currently no common concept for describing patient experience (PEx) in digital health. Neither the general PEx nor user experience (UX) adequately reflects the experience of a patient using a digital service. For example, in a hospital setting, the environment’s cleanliness, background noise, and even food provision could affect PEx [<xref ref-type="bibr" rid="ref20">20</xref>]; however, these factors would not be expected to influence the experience of a patient using a digital service. Similarly, the fact that the system passes usability heuristics does not necessarily mean that the overall experience of a patient using digital health services is positive [<xref ref-type="bibr" rid="ref21">21</xref>]. Therefore, it is vital to understand the experiences of individuals using digital health and how the design of new technologies can affect them [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>].</p>
        <p>The concept of (nondigital) PEx has many definitions in general health care practice and research. The Beryl Institute defines PEx as “the sum of all interactions, shaped by an organization’s culture, that influence patient perceptions, across the continuum of care” [<xref ref-type="bibr" rid="ref24">24</xref>]. Other definitions and studies note that the core elements of optimized PEx include access to appropriate care, patients’ active participation in care, a good patient-physician relationship, reliable evidence-based care, comprehensible information, physical comfort, emotional support, involvement of family and friends, individualized approaches, responsiveness of services, and continuity of care [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref27">27</xref>]. These core elements of PEx help to recognize patients’ priorities when receiving care and in providing patient-centered care. However, patients’ priorities may differ for digital health, in which traditional face-to-face interaction is replaced by human to digital interface interaction. Therefore, to address patient priorities in digital health, it is essential to consider UX in the design of digital health [<xref ref-type="bibr" rid="ref28">28</xref>]. In this study, we define UX as a person’s perceptions and responses that result from the use or anticipated use of a product, system, or service [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Usable, useful, findable, accessible, credible, valuable, and desirable products are more likely to succeed in delivering a positive UX [<xref ref-type="bibr" rid="ref30">30</xref>]. However, the full impact of digital health technologies on PEx or UX still remains unclear [<xref ref-type="bibr" rid="ref31">31</xref>]; some products even result in negative effects such as increased patient anxiety [<xref ref-type="bibr" rid="ref32">32</xref>]. Therefore, more insights into the barriers to and facilitators of individuals’ experiences with digital health are required [<xref ref-type="bibr" rid="ref33">33</xref>].</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>The objectives of this paper were to systematically review (1) the factors that influence PEx in digital health and (2) the design considerations of PEx that are in digital health. The overall aim was to generate a design framework and guidelines for further improving PEx in digital health.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <p>We performed an umbrella systematic review compiling evidence from multiple systematic reviews [<xref ref-type="bibr" rid="ref34">34</xref>] on PEx and UX in digital health. This review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, which is an evidence-based minimum set of items for reporting in systematic reviews and meta-analyses [<xref ref-type="bibr" rid="ref35">35</xref>].</p>
      <sec>
        <title>Digital PEx Working Definition</title>
        <p>Throughout this study, we use the term digital PEx as a working definition to describe people’s experiences in various digital health contexts. As the study progressed, the definition underwent several revisions, which resulted in a more inclusive final definition.</p>
      </sec>
      <sec>
        <title>Search Strategy</title>
        <p>We searched Scopus, PubMed, and Web of Science for studies published between January 1, 2000, and December 16, 2020. The search time window was limited to 2000 as the term digital health was first introduced by Frank [<xref ref-type="bibr" rid="ref36">36</xref>] in 2000. To be inclusive, we used broad interchangeable search terms with varying combinations of digital health, PEx, and UX:</p>
        <list list-type="order">
          <list-item>
            <p>Category 1: “patient experience” OR “health experience” OR “user experience” OR “customer experience” OR “client experience”</p>
          </list-item>
          <list-item>
            <p>Category 2: “ehealth” OR “e-health” OR “mhealth” OR “m-health” OR “telehealth” OR “tele-health” OR “digital health” OR “virtual health” OR “remote health” OR “telemedicine” OR “telemonitoring” OR “teleconsultation”</p>
          </list-item>
          <list-item>
            <p>Category 3: “patient digital experience” OR “patient experience in digital health” OR “e-patient experience” OR “epatient experience” OR “online patient experience”</p>
          </list-item>
        </list>
        <p>After combining categories 1, 2, and 3, limits were set to restrict studies to English-language literature reviews published in journals after 2000. The final search strategy was ([category 1 AND category 2] OR category 3) AND (DOCTYPE [review]) AND (PUBYEAR&#62;2000) AND (LIMIT-TO [SRCTYPE, “journal”]) AND (LIMIT-TO [LANGUAGE, “English”]). Google Scholar was used as an additional database to manually search for additional related references based on the snowballing method during the review process.</p>
      </sec>
      <sec>
        <title>Selection Criteria</title>
        <p>Eligibility criteria were developed for title and abstract screening and refined for full-text screening. The following inclusion criteria were proposed by TW and GG and adjusted by MM and RG:</p>
        <list list-type="order">
          <list-item>
            <p>No duplicated articles</p>
          </list-item>
          <list-item>
            <p>Full text available</p>
          </list-item>
          <list-item>
            <p>English language</p>
          </list-item>
          <list-item>
            <p>Only completed peer-reviewed journal articles</p>
          </list-item>
          <list-item>
            <p>Only review articles</p>
          </list-item>
          <list-item>
            <p>Related to digital health (ie, use of information and communication technology in health) and PEx, UX, or health care experience</p>
          </list-item>
        </list>
      </sec>
      <sec>
        <title>Screening Process</title>
        <p>The collected articles were included in the final analysis if they met all the inclusion criteria after a 2-stage screening process: first, a title and abstract review, followed by a full-text review. In the screening process, 2-round, small random samples (20%) were independently reviewed by 2 reviewers (TW and GG) who evaluated the eligibility of the articles against the selection criteria. The interrater reliability and clarity of the selection criteria were assessed using the Fleiss-Cohen coefficient until it reached the required strength (≥0.60). Uncertainties around paper inclusion and exclusion were resolved by discussions with the research team (TW, GG, MM, and RG) when necessary.</p>
      </sec>
      <sec>
        <title>Data Extraction and Thematic Analysis</title>
        <p>Articles meeting the eligibility criteria were imported into ATLAS.ti (Scientific Software Development GmbH; version 9.0.7; 1857) for data extraction. Data were extracted for the following aspects: (1) study characteristics, including authors, year of publication, research aims, review methods, target users, and digital health intervention (DHI) characteristics; (2) the overall impression of digital PEx (eg, the foci or types of findings regarding digital PEx); (3) influencing factors of digital PEx; and (4) design considerations for improving digital PEx.</p>
        <p>We used the Braun and Clarke 6-phase thematic analysis method [<xref ref-type="bibr" rid="ref37">37</xref>] to analyze the extracted data; these include (1) familiarization with the data, (2) generation of initial codes, (3) searching for themes among codes, (4) reviewing themes, (5) defining and naming themes, and (6) producing the final report (analytical themes). A total of 4 researchers participated in the review process. After data familiarization, a set of a priori categories was defined by TW and refined by all the coauthors (<xref ref-type="table" rid="table1">Table 1</xref>). The coding was based on the Performance of Routine Information System Management (PRISM) framework [<xref ref-type="bibr" rid="ref38">38</xref>], which states that routine HIS performance is affected by the system’s inputs (ie, technical, behavioral [<xref ref-type="bibr" rid="ref39">39</xref>], and organizational determinants) and progress. Please note that other elements of the framework (outputs, outcomes, and impact) are discussed in another study addressing the evaluation of digital PEx (work in progress).</p>
        <p>Group discussions among the authors were used to reach an agreement on the produced a priori categories. TW quoted the relevant data across the included reviews, generated initial codes based on a priori categories, and then searched for themes among codes. Frequently used terms in the included reviews were used as inspiration to generate subsequent codes and themes. The latter process was independently and randomly validated by GG, MM, and RG.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>A priori categories of influencing factors of digital patient experience based on the Performance of Routine Information System Management framework [<xref ref-type="bibr" rid="ref38">38</xref>].</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="200"/>
            <col width="0"/>
            <col width="770"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Determinants and a priori categories</td>
                <td>Description</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="4">
                  <bold>Behavioral determinants</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Patient capability</td>
                <td colspan="2">The individual’s psychological and physical capacity to engage in the concerned digital health activity</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Patient opportunity</td>
                <td colspan="2">The individual’s internal conditions that enable or disrupt patients to engage in digital health</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Patient motivation</td>
                <td colspan="2">The reflective and automatic brain processes that energize and direct patients’ goal setting and decision-making and their behaviors regarding using digital health</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Technical determinants</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Intervention technology</td>
                <td colspan="2">The integration of telecommunications and computers, as well as necessary enterprise software, middleware, and storage and audiovisual software, which enables users to access, store, transmit, understand, and manipulate health information</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Intervention functionality</td>
                <td colspan="2">The ability of digital health to work as expected to help users meet their health goals and needs</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Intervention interaction design</td>
                <td colspan="2">The process of moving digital health from its existing state to a preferred state to optimize interactions between patients and digital health interventions</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Organizational determinants</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Organizational environment</td>
                <td colspan="2">The management of the health service system, as affected by the rules, values, and practices of the involved people or community</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Physical environment</td>
                <td colspan="2">The tangible surroundings (such as space, light, or sound) around patients, which affects their interactions with digital health</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Social environment</td>
                <td colspan="2">The cultural environment (such as policy, business, or customs) that affect patients’ interactions with digital health</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Overview</title>
        <p><xref rid="figure1" ref-type="fig">Figure 1</xref> shows the flow diagram of the systematic search. A total of 173 records were generated after the computer search; 58 (33.5%) duplicates were removed, and the titles and abstracts of 115 (66.5%) articles were reviewed. Subsequently, 53.9% (62/115) of full-text articles (including 4 additional records collected through snowballing) were reviewed for inclusion. Ultimately, 45 studies were included in the review for data extraction.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Study flow diagram. ICT: information and communications technology.</p>
          </caption>
          <graphic xlink:href="jmir_v24i8e37952_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Study Characteristics</title>
        <p>Embase, MEDLINE, PubMed, PsycINFO, CINAHL, and the Cochrane Library were the most common databases for the included reviews. Of these, 62% (28/45) were systematic review articles. The remainder included scoping reviews (6/45, 13%), literature reviews (3/45, 7%), integrative reviews (3/45, 7%), narrative reviews (2/45, 4%), comprehensive overviews (1/45, 2%), review of systematic reviews (1/45, 2%), and umbrella reviews (1/45, 2%). More than half of the included reviews (24/45, 53%) conducted quality assessments. The reviews included &#62;1400 studies, which mainly or partially reported qualitative and quantitative analyses of PEx in digital health. The data analysis methods varied and included thematic analysis (8/45, 18%), meta-synthesis (5/45, 11%), meta-ethnography synthesis (2/45, 4%), taxonomy (1/45, 2%), hermeneutic synthesis (1/45, 2%), qualitative evidence synthesis (1/45, 2%), and state-of-the-art survey analysis (1/45, 2%).</p>
        <p>Among the included reviews, some focused on specific populations, such as children (3/45, 7%), college students (1/45, 2%), younger people (1/45, 2%), adults (7/45, 16%), or older adults (4/45, 9%). Others either focused on the general population or did not mention the target population. The most common health issues across the included articles were chronic diseases (17/45, 38%), including chronic obstructive pulmonary disease, heart failure, cardiovascular disease, cancer, diabetes, and hypertension. Mental health problems (7/45, 16%), including depression, anxiety, psychological well-being, psychotic disorders, and schizophrenia, were the second most common health issues. The remainder either focused on other issues (8/45, 18%), including audiology, asthma, reproductive health, maternal health, newborn health, child health, adolescent health, surgery, postpartum, somatic diseases, or palliative care, or did not mention any specific health issues (14/45, 31%). Some papers (8/45, 18%) also provided multistakeholder perspectives, including health care professionals, providers, surgeons, clinicians, staff and organizations, implementers (such as health policy makers, clinicians, and researchers), and the participation of information technology.</p>
        <p>The degree of detail provided about the interventions varied greatly across the studies. Phone-based apps, websites, handheld sensing devices, and ambient assisted living health care systems were common digital health deliveries. Interaction techniques included synchronous, asynchronous, and hybrid models. Diverse intervention platforms, systems, or functions were used to deliver various health care services, including supporting disease management (14/45, 31%); patient-to-physician communication or consultation (9/45, 20%); symptom monitoring (9/45, 20%); information transmission (4/45, 9%); health promotion activities (3/45, 7%); screening, diagnosis, or self-assessment (2/45, 4%); behavior changes (2/45, 4%); self-education (1/45, 2%); and decision-making (1/45, 2%). <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref83">83</xref>] provides detailed information regarding the characteristics of the included studies.</p>
      </sec>
      <sec>
        <title>Overall Impression of Digital PEx</title>
        <p>Our study revealed great diversity in the perspectives and definitions describing patients’ experiences and characteristics when using digital health, presenting a variety of influencing factors and design considerations for digital PEx. The included studies showed different foci regarding digital PEx, including influencing factors (21/45, 47%) [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref59">59</xref>], digital health performance (19/45, 42%) [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>-<xref ref-type="bibr" rid="ref68">68</xref>], patient perceptions (9/45, 20%) [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref73">73</xref>], evaluation methods of digital health or digital PEx (8/45, 18%) [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref74">74</xref>-<xref ref-type="bibr" rid="ref79">79</xref>], and design considerations (9/45, 20%) [<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>-<xref ref-type="bibr" rid="ref82">82</xref>]. The findings and conclusions of the 45 reviews showed a great diversity. Most studies presented a set of themes (19/45, 42%) [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref79">79</xref>] or descriptions only (16/45, 36%) [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. Other studies concluded with a theory-based description (5/45, 11%) [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref80">80</xref>], framework (4/45, 9%) [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref82">82</xref>], model (2/45, 4%) [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref69">69</xref>], method (2/45, 4%) [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], or checklist (1/45, 2%) [<xref ref-type="bibr" rid="ref59">59</xref>]. Only a few studies transformed findings into design considerations (9/45, 20%) or visualized or structured their results into frameworks, models, checklists, or methods (9/45, 20%). Limited information was found on participant dropout reasons during the interventions [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]. The overall impression of the researchers on the DHIs was positive. In 51% (23/45) of reviews [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref61">61</xref>-<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref80">80</xref>], the DHIs either showed promising results or at least results comparable with face-to-face health care services. Only 4% (2/45) of reviews [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref60">60</xref>] reported concrete evidence of the negative impact of current DHIs on digital PEx. In general, digital PEx was addressed because of the interactions between the DHIs and the patients involved and how the service was organized and carried out.</p>
      </sec>
      <sec>
        <title>Influencing Factors of Digital PEx</title>
        <p>An influencing factor is an aspect of the existing situation that influences other aspects of the situation, and it is formulated as an attribute of an element that is considered relevant and can be observed, measured, or assessed [<xref ref-type="bibr" rid="ref84">84</xref>]. In this study, influencing factors refer to specific factors that lead to a positive or negative experience (digital PEx). Some factors have either positive or negative consistent and concrete impacts, whereas others have double-edged impacts; that is, impacts that are different per individual or change over time. Among the included papers, a common understanding of the potential influencing factors was captured from 3 aspects—behavioral, technical, and organizational determinants—following the categorization of the PRISM framework. These determinants were each classified into 3 categories, resulting in nine categories: patient capability, patient opportunity, patient motivation, intervention technology, intervention functionality, intervention interaction design, organizational environment, physical environment, and social environment. <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref83">83</xref>] presents an overview of the themes identified for each category, the influencing factors per theme (positive, negative, and double-edged), and references. Most factors appear to be related to technical determinants, followed by behavioral and organizational determinants. For <italic>technical determinants</italic>, we summarized 3 categories with 13 themes, containing 58 positive, 35 negative, and 13 double-edged factors. For example, DHIs with multiple behavioral change techniques appeared to be more effective [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref80">80</xref>] and reported higher patient satisfaction [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. <italic>Behavioral determinants</italic> included 3 categories with 9 themes containing 11 positive, 21 negative, and 5 double-edged factors. For instance, some studies mentioned a lack of confidence in patients’ own ability to use the technology [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], leading to a negative digital PEx. <italic>Organizational determinants</italic> were classified into 3 categories with 5 themes, including 13 positive and 23 negative factors. For example, unrealistic financial reimbursement and higher costs related to the internet or equipment were practical challenges of using digital health [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. For the behavioral and organizational determinants, we collected more negative factors than positive factors. This is in contrast to the technical determinants, in which more positive factors were identified. Double-edged factors were less than both positive and negative factors for all the 3 determinants. <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref75">75</xref>-<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref80">80</xref>-<xref ref-type="bibr" rid="ref83">83</xref>] provides detailed information and examples.</p>
      </sec>
      <sec>
        <title>Design Considerations of Digital PEx</title>
        <p><xref ref-type="table" rid="table2">Table 2</xref> provides an overview of the identified themes for each design construct or method, related considerations, and references. To address the abovementioned influencing factors, several the included articles referred to <italic>design constructs</italic> (personalization, information, navigation, and visualization) [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>] and <italic>design methods</italic> (ie, human-centered design [HCD] or user-centered design [UCD], co-design or participatory design, and inclusive design) [<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref80">80</xref>-<xref ref-type="bibr" rid="ref82">82</xref>], either as recommendations or implications for improving digital PEx from a design perspective. Notably, there was an overlap between design considerations and influencing factors. The former focuses on concluding possible design suggestions, recommendations, and implications proposed by the reviewed articles. The latter involves mapping the impacts of interaction design on digital PEx in different contexts; therefore, they refer to different themes and references. Generally, the <italic>personalization construct</italic> identifies patient profiles and tailors digital health according to patients’ needs and preferences. The <italic>information construct</italic> addresses the source, language, presentation, content, and architecture of delivered health information. The <italic>navigation construct</italic> considers the interactive, delivered, and instructional elements of digital health to guide users to different areas of content within digital health. The <italic>visualization construct</italic> focuses on the aesthetics, attractiveness, visibility, and consistency of digital health appearance and interface. Furthermore, co-design and UCD or HCD were recommended as the most common methods for designing digital health, which involve multi-stakeholders and multi-disciplinaries in the design process to facilitate the designers’ work, as designers need to understand end user needs and be aware of potential barriers to engaging in DHIs. Finally, <italic>inclusive design</italic> provides flexible design and is usable for a broader population. Notably, the design considerations identified in the included papers are not meant to be applied to every project; the implementation depends on the project’s focus. Designers always need to balance project requirements (such as profits), user needs (such as privacy concerns), and policy regulations (such as data security). For example, peer-to-peer patient communication may not be appropriate for more sensitive health issues.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Design considerations of digital patient experience.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="30"/>
            <col width="200"/>
            <col width="0"/>
            <col width="560"/>
            <col width="0"/>
            <col width="180"/>
            <thead>
              <tr valign="top">
                <td colspan="4">Themes</td>
                <td colspan="2">Considerations</td>
                <td>References</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="7">
                  <bold>Design constructs</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Personalization</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Profiling</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Careful patient selection for digital health use</p>
                    </list-item>
                    <list-item>
                      <p>Assess specific metrics (eg, sociodemographic characteristics, basic health status, individual preferences, and habits)</p>
                    </list-item>
                    <list-item>
                      <p>Create an accurate patient profile</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Tailoring</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Provide personalized information, tailored intervention content, and customized feedback (eg, predicted possible causes and consequences of a health problem and advice on the behavior under investigation)</p>
                    </list-item>
                    <list-item>
                      <p>Tailor the content to the user’s needs and preferences</p>
                    </list-item>
                    <list-item>
                      <p>Tailor images, colors, text quantity, and font size and color to what users find appealing</p>
                    </list-item>
                    <list-item>
                      <p>Tailor multiple variables rather than a single variable</p>
                    </list-item>
                    <list-item>
                      <p>Align with end users’ habitual routines</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Autonomy</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Choose desirable and accessible forms of delivery</p>
                    </list-item>
                    <list-item>
                      <p>Choose when and how to receive reminders</p>
                    </list-item>
                    <list-item>
                      <p>Select or change personalized goals for future use throughout the time span of intervention</p>
                    </list-item>
                    <list-item>
                      <p>Select preferred styles (eg, color and font)</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Information</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Content</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Provide comprehensive health information (eg, medical history, test results, and medication information)</p>
                    </list-item>
                    <list-item>
                      <p>Provide appropriate education and training on a health condition</p>
                    </list-item>
                    <list-item>
                      <p>Provide concise information (not overwhelm)</p>
                    </list-item>
                    <list-item>
                      <p>Provide evidence-based information from a credible source (eg, no advertisements and validated advice)</p>
                    </list-item>
                    <list-item>
                      <p>Appropriate encryption and digital health security (eg, password setting and privacy policy)</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Communication</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Provide peer-to-peer communication through web-based forums and communities using instant messages</p>
                    </list-item>
                    <list-item>
                      <p>Access to professionals directly via email, SMS text message, or live chat</p>
                    </list-item>
                    <list-item>
                      <p>Share duties between health care staff</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Functionality</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Rewards (eg, material incentives, intangible rewards, and messages of congratulations when a task is completed)</p>
                    </list-item>
                    <list-item>
                      <p>Reminders (eg, email messages, SMS text messages, words of the day, and pop-ups) for task completion</p>
                    </list-item>
                    <list-item>
                      <p>Reflective feedback, persuasive features, and gaming features (eg, knowledge quizzes and games)</p>
                    </list-item>
                    <list-item>
                      <p>Functional characteristics enable accurate and continuous self-management (eg, activity planning, activity tracking, self-monitoring, and diaries), person-centered care, and sustained behavior change</p>
                    </list-item>
                    <list-item>
                      <p>Appropriate dose of treatment</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Navigation</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Forms of delivery</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Readily accessible and downloadable</p>
                    </list-item>
                    <list-item>
                      <p>Improve DHI<sup>a</sup> delivery (eg, change from a website to a mobile phone app)</p>
                    </list-item>
                    <list-item>
                      <p>Ability to print and email the information</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>User flows</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Minimum input (eg, voice commands)</p>
                    </list-item>
                    <list-item>
                      <p>Efficient access to information</p>
                    </list-item>
                    <list-item>
                      <p>Clarify what to do next</p>
                    </list-item>
                    <list-item>
                      <p>Provide search bar and menu bar</p>
                    </list-item>
                    <list-item>
                      <p>Tools and aids to help understand health information and complete health tasks</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Instruction and tutorials</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Guide users to a greater extent if the design is not self-explanatory</p>
                    </list-item>
                    <list-item>
                      <p>Provide more concrete, explicit, and context-sensitive instructions (eg, a virtual guided tour and extra internal links)</p>
                    </list-item>
                    <list-item>
                      <p>Adopt features from common (ie, familiarized) user interfaces (eg, the iPhone interface)</p>
                    </list-item>
                    <list-item>
                      <p>Provide appropriate education and training on digital health use</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Visualization</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Message presentation</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Visualize continuous monitoring data (eg, present data as graphs and tables)</p>
                    </list-item>
                    <list-item>
                      <p>Provide a coherent presentation in terms of colors, pictures, and themes</p>
                    </list-item>
                    <list-item>
                      <p>Simple nontechnical language</p>
                    </list-item>
                    <list-item>
                      <p>Straightforward and concise text</p>
                    </list-item>
                    <list-item>
                      <p>Comprehensive descriptions of actionable message</p>
                    </list-item>
                    <list-item>
                      <p>Provide positive, nonauthoritarian, friendly, and nonjudgmental tone of voice</p>
                    </list-item>
                    <list-item>
                      <p>Multimedia messages (eg, text combined with relevant pictures or video)</p>
                    </list-item>
                    <list-item>
                      <p>Highlight information using various font styles, sizes, and colors</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref59">59</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Interface aesthetic</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Show graphics (ie, visual aids) rather than (too much) text</p>
                    </list-item>
                    <list-item>
                      <p>Provide a pleasing color scheme (eg, bright colors)</p>
                    </list-item>
                    <list-item>
                      <p>Simple interface</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]</td>
              </tr>
              <tr valign="top">
                <td colspan="7">
                  <bold>Design methods</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Co-design and participatory design approaches</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Multistakeholder</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Involve end users and other stakeholders</p>
                    </list-item>
                    <list-item>
                      <p>Include the user at the beginning of the design process</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Interdisciplinary</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>An interdisciplinary approach to the development and implementation</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>User-centered design and human-centered design approaches</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Needs assessment</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Know the needs, capabilities, and environment of users through focus groups, surveys, interviews, and personas</p>
                    </list-item>
                    <list-item>
                      <p>Composing, preparing, and organizing content</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Usability testing</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Gain early feedback from users through prototypes; benchmark testing, user testing, heuristic analysis, failure modes and effects analysis, and observations in other health care settings</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Implementation</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Fit the technology to the person, not the person to the technology; pilot testing, task analysis, and reporting mechanism</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Monitor and sustain</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Understanding work as imagined often differs from work as done; pre- and posttesting, contextual inquiry, and safety and hazard reporting</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref82">82</xref>]</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Inclusive design approaches</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Inclusive</td>
                <td colspan="2">
                  <list list-type="bullet">
                    <list-item>
                      <p>Provide a flexible design that is usable by people with no limitations, as well as by people with functional limitations related to disabilities or old age</p>
                    </list-item>
                  </list>
                </td>
                <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>DHI: digital health intervention.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Design Implications</title>
        <p>On the basis of our findings regarding influencing factors and design considerations for digital PEx, in this section, we define digital PEx and present design guidelines for the implementation of improving PEx in digital services.</p>
        <sec>
          <title>Definition of Digital PEx</title>
          <p>Our review reveals the absence of a commonly used concept for PEx in digital health. An increasing number of studies have been conducted on surveying PEx, satisfaction with, and expectations in varied digital health. With the growing academic interest in this topic and increasing efforts to address PEx in digital health design practice, a common concept with a concise definition will strengthen and align efforts overall. After reviewing the alignment of widely accepted concepts of PEx, UX, and DHIs with our generated influencing factors, we observed that many of our findings are included in the PEx definition offered by The Beryl Institute. Therefore, by including the sum of all interactions shaped by an organization’s culture, which influence patient perceptions across the continuum of care [<xref ref-type="bibr" rid="ref33">33</xref>] along with the constructs of UX (people’s perceptions and responses [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]), DHIs (digital health technologies [<xref ref-type="bibr" rid="ref13">13</xref>]), and the determinants (ie, technical, behavioral, and organizational determinants) identified in this review, we propose a concise, practical definition of digital PEx to guide the future design of digital health: “Digital patient experience is the sum of all interactions, affected by a patient’s behavioral determinants, framed by digital technologies, and shaped by organizational culture, that influence patient perceptions across the continuum of care channeling digital health.” Compared with the original definition of general PEx, this new definition underlines the digital part of health care delivery and includes 2 new determinants (technical and behavioral) that go beyond the organization’s culture to clarify what can influence patient perceptions while traveling along a digital care pathway.</p>
        </sec>
        <sec>
          <title>Design Guidelines for Improving Digital PEx</title>
          <p>We developed a design and evaluation framework to help digital health designers or developers improve digital PEx in the design process (<xref rid="figure2" ref-type="fig">Figure 2</xref>). This framework was based on the findings of this umbrella review and was inspired by the double diamond model [<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Our framework shows four phases: <italic>define design, define evaluation, design ideation,</italic> and <italic>design</italic> <italic>evaluation</italic>. The first and third phases focus on the design itself, and the second and fourth phases focus on design evaluation. In this study, we focus on explaining the first and third phases. In the first phase, designers must define the design goals by considering the factors that affect digital PEx. In this phase, we provided 3 determinants referring to 9 categories of influencing factors that have 3 types of impact on digital PEx (positive, negative, and double-edged) for designers to discover and explore. Designers can frame their design goals based on the intervention purposes and the selection of influencing factors. For example, if the purpose of the intervention is to improve patient eHealth literacy, designers need to pay more attention to patient capability and frame a design goal to develop suitable intervention functionality for improving patient capability. After defining the design goals, designers can move to the second phase, which is the <italic>define evaluation</italic> phase. In this phase, designers need to consider evaluation indicators (patient emotional, behavioral, and health outcomes) and evaluation methods (surveys and interviews) that are used to assess digital PEx. Detailed information regarding this phase will be discussed in a parallel study. Following this, we provide 4 design constructs (personalization, information, navigation, and visualization) and 3 design methods (ie, HCD or UCD, co-design, and inclusive design) for the design ideation phase. <italic>Personalization</italic> [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref87">87</xref>] refers to ascertaining user needs with design goals. It encompasses the design of intervention technology and functionality needs that meet the patients’ ability, opportunity, and motivation to trigger behavior changes and promote health outcomes. <italic>UCD/HCD</italic> and <italic>inclusive design</italic> are valuable at this stage for the inclusion of patient perspectives. Driven by user needs and intervention goals, <italic>information</italic> includes content, communication, and functionality [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], and <italic>navigation</italic> comprises forms of delivery, user flows, instructions, and tutorials [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]. This relates to how relevant content presented in multimedia with a clear information architecture can attract patient attention and help them understand and complete tasks efficiently [<xref ref-type="bibr" rid="ref88">88</xref>]. <italic>Co-design</italic> and <italic>participatory design</italic> are multidisciplinary collaborations that are necessary at these 2 stages. Finally, designers need to consider <italic>visualization</italic> [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], which determines the product look. The digital health interface can affect patients’ first impressions when using DHIs. An attention-grabbing, simple, and consistent interface [<xref ref-type="bibr" rid="ref59">59</xref>], layout (colors and images) [<xref ref-type="bibr" rid="ref80">80</xref>], and message presentation [<xref ref-type="bibr" rid="ref59">59</xref>] can all lead to positive UX. The design guidelines (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>) can be used at this stage to produce design concepts. In addition, this phase contains the digital health design workflow, challenges, and tips from a design practice perspective (which will be presented in an ongoing interview study). Finally, we ended up with this framework by introducing the design evaluation phase, in which designers need to develop tests (based on evaluation metrics) to evaluate design concepts. If the evaluation outcomes do not meet the evaluation standards, designers can return to the design ideation phase to adjust the design concepts or return to the first phase to reconsider the design goals.</p>
          <p>Compared with the original double diamond model, our framework separates the evaluation part from the design part. This aligns with the design research methodology framework [<xref ref-type="bibr" rid="ref84">84</xref>], which suggests generating success criteria after clarifying design research goals and before producing design support, formulating criteria for success is essential to be able to determine whether the results help achieve this aim. Therefore, we paid equal attention to design and evaluation. In addition, our framework provides detailed reference materials (such as 3 determinants) for each phase to provide designers with more practical support. Notably, in our framework, we retain some typical features of the double diamond model: the first 2 phases are research related, the last 2 phases are practice related, and each phase starts from divergence and ends at convergence.</p>
          <p>On the basis of our findings on influencing factors and design considerations, we mapped the combinations of design constructs and design methods into 9 design guidelines to address different influencing factors (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>), which can be used to guide the design ideation process. Some of the design guidelines uncovered in this study have already been implemented, resulting in a positive digital PEx, such as the digital platform PatientsLikeMe, which aims to empower patients to navigate their health journeys together through peer support, personalized health insights, tailored digital health services, and patient-friendly clinical education [<xref ref-type="bibr" rid="ref89">89</xref>]. One of the studies pointed out that patients can greatly benefit from using this platform as it improves patient health literacy, and its condition-specific customization may still further improve PEx [<xref ref-type="bibr" rid="ref90">90</xref>], which aligns with our design guidelines on improving “patient capability” and providing “personalized information.”</p>
          <fig id="figure2" position="float">
            <label>Figure 2</label>
            <caption>
              <p>Digital patient experience design and evaluation framework. HCD: human-centered design; UCD: user-centered design.</p>
            </caption>
            <graphic xlink:href="jmir_v24i8e37952_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
          <boxed-text id="box1" position="float">
            <title>Design guidelines for improving digital patient experience.</title>
            <p>
              <bold>Categories and design guidelines</bold>
            </p>
            <list list-type="bullet">
              <list-item>
                <p>Patient capability</p>
                <list>
                  <list-item>
                    <p>Identify patients’ knowledge and skill levels by understanding their technology, language, and health literacy; consider their previous experience and current confidence level in using digital health; improve their actual literacy and correct their perceived inability; tailor design to their ability</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Patient opportunity</p>
                <list>
                  <list-item>
                    <p>Profile patients’ identity (eg, age, gender, economic status, and daily routines) and health status (eg, illness complexity, severity, and stability); consider patients’ accessibility and affordance to digital health; tailor design to their individual opportunity</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Patient motivation</p>
                <list>
                  <list-item>
                    <p>Recognize patients’ mindset and perceived advantages and disadvantages; inform them of the potential benefits of using digital health; address their concerns and worries; understand their expectations and needs; tailor design to their preferences to trigger their motivation</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Intervention technology</p>
                <list>
                  <list-item>
                    <p>Increase technical usability; ensure ease of use, ready to use, and timely feedback on digital health; select technical features (eg, data accessibility) and delivery media or devices (eg, device ownership) to meet patients’ preferences and needs</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Intervention functionality</p>
                <list>
                  <list-item>
                    <p>Strengthen theory-based interventions (eg, behavior change techniques and evidence-based interventions); improve intervention quality, considering privacy, security, and accuracy issues; provide regular and continuous social support combining both remote communication and real human contact; tailor health promotion and intervention structure to patients’ needs and preferences</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Intervention interaction design</p>
                <list>
                  <list-item>
                    <p>Provide personalized and consistent information, clear tutorials or technical support, and visualized data; allow patients to choose personalized interactive elements; follow human or user-centered design, co-design, and inclusive design methods; involve multi-stakeholders and multi-disciplines in the design process</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Organizational environment</p>
                <list>
                  <list-item>
                    <p>Reduce equipment or service cost and time; improve health care providers’ professional ability, communication skills, and service attitudes across the use of digital health; increase workflow transparency and clarify accountability; improve system integration and compatibility</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Physical environment</p>
                <list>
                  <list-item>
                    <p>Provide a familiar, warm, and comfortable environment rather than cold and unfamiliar settings; reduce environmental distractions (eg, background noise or lighting)</p>
                  </list-item>
                </list>
              </list-item>
              <list-item>
                <p>Social environment</p>
                <list>
                  <list-item>
                    <p>Provide adequate support policies and legislation; develop plausible business cases</p>
                  </list-item>
                </list>
              </list-item>
            </list>
          </boxed-text>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>We systematically reviewed review articles on factors that influence digital PEx and considerations regarding how best to design digital PEx. The reviews varied greatly in type, including studies and data analysis methods, as well as in HIS, health issues, target patient groups, intervention content, and structure. Of the selected reviews, 62% (28/45) were systematic reviews, the rest were <italic>other</italic> types. These included qualitative, quantitative, and mixed methods studies. Thematic analysis and meta-analysis were the most common data analysis methods used in the reviews. We note that the studies described in the selected reviews were extremely heterogeneous, and information about interventions and digital PEx were often mixed and complex, making comparison difficult.</p>
        <p>Our results are in line with the findings reported by previous authors [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref38">38</xref>] on the factors that affect PEx, UX, or the implementation of digital health. On the basis of the identified influencing factors and design considerations, we developed 9 design guidelines for improving digital PEx. Our findings reveal that among the selected reviews, only a few formulated design strategies or guidelines. This lack of design knowledge transformation makes it difficult for designers or developers to apply the findings directly. This aligns with the studies by Sakaguchi-Tang et al [<xref ref-type="bibr" rid="ref48">48</xref>] and Søgaard Neilsen and Wilson [<xref ref-type="bibr" rid="ref80">80</xref>]; the former indicated that the absence of specific design recommendations impairs the design of digital health, with the latter suggesting that there was a lack of understanding of the most beneficial design aspects for some specific digital health and how design principles can best be applied. Moreover, the use of UCD has been recommended in many studies to address UX-relevant issues in digital health [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref91">91</xref>], which also supports our findings.</p>
      </sec>
      <sec>
        <title>Digital PEx Versus General PEx and UX</title>
        <p>We found a lack of a common term to describe PEx in digital health; UX (25/45, 56%) and PEx (17/45, 38%) were the most commonly used terms. Patient UX, patient perceptions, client experiences, patient empowerment, and user engagement were also used to describe similar concepts. Many reviews indicated that there was limited information about UX or PEx in varied digital health and underlined the need for a more holistic view of patient needs and priorities to better shape digital health design strategies and provide tailored digital health [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref74">74</xref>].</p>
      </sec>
      <sec>
        <title>Influencing Factors Are More Complex Than Facilitators and Barriers</title>
        <p>The information provided about digital PEx–influencing factors was complex and heterogeneous. Digital health is often treated as a whole, whereas digital PEx is affected by the additive effect of varying digital health factors. A single change in a factor may affect everything else. We found that without a concrete interaction context, factors could be regarded concurrently with facilitators or barriers. For example, regular contact with health care providers (HCPs) could be perceived to increase a sense of reassurance or perceived as a burden to patients’ daily lives [<xref ref-type="bibr" rid="ref28">28</xref>]; some patients experienced digital health as time consuming or an additional burden, whereas others experienced it as time saving or convenient [<xref ref-type="bibr" rid="ref69">69</xref>]. Some influencing factors may have a soft or indirect influence on digital PEx [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref76">76</xref>]. For instance, users who are completely unaware of privacy or security risks may have excellent experience with digital health that fails to meet privacy or security requirements [<xref ref-type="bibr" rid="ref76">76</xref>]. A lack of concrete solutions to address these barriers was mentioned [<xref ref-type="bibr" rid="ref48">48</xref>]. It is likely that digital health cannot serve all populations equally well [<xref ref-type="bibr" rid="ref71">71</xref>], which aligns with the results of a scoping review that investigated the inequities caused by the adoption of digital health technologies [<xref ref-type="bibr" rid="ref92">92</xref>]. Some researchers indicated that older adults can also experience benefits by using digital health [<xref ref-type="bibr" rid="ref53">53</xref>], whereas others suggested that telehealth is, at best, a partial solution for younger and fitter subpopulations [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]. Again, although some mentioned that patients preferred using personal devices [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], others noted the opposite [<xref ref-type="bibr" rid="ref64">64</xref>].</p>
      </sec>
      <sec>
        <title>Unclear Benefit From the Different Elements in Digital Health</title>
        <p>It is likely that some patient groups benefit more than others from specific DHIs. For example, one of the reviews suggested that in telemedicine treatment for type 2 diabetes, behavioral change and continuous management were the keys to success [<xref ref-type="bibr" rid="ref43">43</xref>]. However, it was unclear precisely which elements of digital health resulted in patients’ satisfaction or dissatisfaction and how they could be addressed [<xref ref-type="bibr" rid="ref83">83</xref>]. Moreover, we found limited data and even contradictory results on which factors affect digital PEx the most, which elements should be considered first when developing DHIs, and who benefits more from them. The latter is commonly mentioned [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref70">70</xref>], with some authors suggesting that patients with unstable chronic diseases might benefit the most [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref93">93</xref>]. However, another review indicated that even if patients are provided with the latest state-of-the-art technology at home, the intervention will not be beneficial if it remains unused [<xref ref-type="bibr" rid="ref43">43</xref>]. Patients who are less activated are likely to have less positive experiences than those who are highly engaged [<xref ref-type="bibr" rid="ref74">74</xref>].</p>
      </sec>
      <sec>
        <title>Lack of Multiple Perspectives During the Design of Digital PEx</title>
        <p>Clear communication between experts, designers, and patients regarding their understanding of digital PEx is required. Some reviews acknowledged the need for a multistakeholder perspective on digital PEx [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. However, we found circumstances in which this was not possible. For example, in some cases, UCD for DHIs was conducted on nonpatient users either because of ethical reasons or relevant regulations [<xref ref-type="bibr" rid="ref43">43</xref>], and in others, apps that are not specifically designed for patients with cancer were being used for this patient group [<xref ref-type="bibr" rid="ref64">64</xref>]. HCPs are often isolated from the decision-making process to incorporate digital health into their current service provision [<xref ref-type="bibr" rid="ref28">28</xref>]. Moreover, a lack of clinician perceptions of digital health use was also reported [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]. Furthermore, no studies focused on exploring designers’ views, opinions, experiences, or values in addressing PEx or UX in the design of digital health. There was little information on whether experienced designers had worked with patients in their design process.</p>
      </sec>
      <sec>
        <title>Over- or Underestimated Results</title>
        <p>Some studies suggested that a lack of interest was the main reason for patients’ refusal of digital health and that reasons for patient withdrawal were patients not wanting to use equipment, deteriorating health, and technical problems [<xref ref-type="bibr" rid="ref94">94</xref>,<xref ref-type="bibr" rid="ref95">95</xref>]. We need to gain better insights into the reasons for patients choosing not to engage in or withdraw from digital health, as these will significantly inform future DHI development and design [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. However, it is likely that most studies only included patients who had already agreed to or were using digital health technologies; those who refused to use, withdrew from, or had no accessibility were excluded [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]. One of the reviews suggested that this would result in over- or underestimated results of DHIs’ effects on digital PEx, as participants who completed the intervention may differ from those who did not [<xref ref-type="bibr" rid="ref41">41</xref>]. Another review found that patients only reported positive themes associated with remote monitoring, which may indicate a selection bias [<xref ref-type="bibr" rid="ref71">71</xref>].</p>
      </sec>
      <sec>
        <title>Conflicts Between Benefits and Cost for Developing DHIs</title>
        <p>The provision of digital health can reduce the treatment burden and better integrate care into patients’ daily routines [<xref ref-type="bibr" rid="ref69">69</xref>], which is consistent with our findings; we found that most reviews had a positive perspective of DHIs. However, in one of the reviews, it was suggested that although there was agreement among most professionals that health information technology can have a positive impact on PEx, when weighing the benefits against the potential cost, demonstrating this will be challenging [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. Moreover, unnecessary high-frequency monitoring could result in a waste of health resources and an increased workload for HCPs [<xref ref-type="bibr" rid="ref52">52</xref>]. Compared with existing health care services, the application of new technology needs to demonstrate clinical evidence of improved health conditions [<xref ref-type="bibr" rid="ref43">43</xref>]. However, there were discordant findings in terms of the benefits of using DHIs. For example, there was no concrete evidence that telemedicine consultations were quicker than face-to-face consultations [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. In another case, the impact of DHIs on health care use was not examined [<xref ref-type="bibr" rid="ref57">57</xref>]. In conclusion, only user-friendly and quality-certified DHIs should be provided to patients [<xref ref-type="bibr" rid="ref64">64</xref>]; health care organizations should not shift their focus from the basic and inexpensive strategies that affect patient care. Care is needed: new technology should not overwhelm the patient or ignore patient needs [<xref ref-type="bibr" rid="ref44">44</xref>].</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>First, when undertaking a review of review articles, some important details included in the original studies may have been lost, which increases the possibility of reporting bias. We also noted differences in the interpretation of terms and methods between the reviews. There is a lack of consistency in the terminology used to describe the functions of DHIs, HISs, or digital PEx itself. For example, in some cases, “eHealth” and “mHealth” were used as interchangeable terms [<xref ref-type="bibr" rid="ref75">75</xref>], “persuasive technology” and “behavior change techniques” were presented as having a similar meaning [<xref ref-type="bibr" rid="ref43">43</xref>], and “patient engagement” and “patient activation” were also regarded as being the same [<xref ref-type="bibr" rid="ref74">74</xref>]. This inconsistent use of terms may impede knowledge translation and dissemination [<xref ref-type="bibr" rid="ref57">57</xref>]. To counter this, we summarized the varied factors with unified descriptions to build a common understanding of the digital PEx–influencing factors.</p>
        <p>Second, the intervention types and patient groups varied widely among the reviews, limiting meaningful comparisons between different studies. In addition, the digital health landscape is rapidly evolving, and the technology infrastructure is constantly shifting [<xref ref-type="bibr" rid="ref41">41</xref>], as are the continuous updates of the UX design area. It is important to keep the influencing factors updated or adapted as the technology develops. Possibly, relevant original studies may have been excluded because of our focus on review papers. However, our approach to conducting an overarching review provides readers with a quick overview of the relevant digital PEx studies and a basis for further research.</p>
        <p>Third, our umbrella review did not account for the multimodal relationships between subthemes or the potential overlap between subthemes within different domains. For example, different subthemes, such as “personalized design” in “interventions’ interaction design” also interconnect with “interventions’ technology” and “interventions’ functionality.” Moreover, our review process did not aim to address the question of whether some influencing factors are more important than others or how different aspects of DHIs influence them. This warrants further investigation as we suspect that differences may exist between the influencing factors, as some elements in digital health are more likely to increase or inhibit a positive digital PEx.</p>
        <p>Finally, as we used qualitative thematic analysis to synthesize the findings and generate themes, the generated themes could have been influenced by the authors’ previous research experiences and personal understanding. By asking other researchers to repeat the coding process, the resulting themes are likely to be different. However, to minimize the potential coding bias, the generation of categories was based on the PRISM framework; 4 researchers with different backgrounds, including design, medical, and human factors, were involved in the iterative coding process, group discussion, and independent and random validation, and existing theories were used.</p>
      </sec>
      <sec>
        <title>Further Research</title>
        <p>The goals of this umbrella review were to systematically review the influencing factors that affect digital PEx and the design considerations for improving digital PEx that are summarized in the existing literature. We must conclude that, currently, much remains unknown, and the topic of digital PEx is relatively new. We propose 6 directions that require further research. The first direction is to develop frameworks or models that translate digital PEx–related research findings into design practices or implications. For example, in this study, we used design guidelines and a design framework to summarize the findings. The second direction is to identify those who will benefit more from which elements in DHIs and which influencing factors could be addressed by combining design constructs and design methods. The third direction is to further examine how designers understand and address digital PEx in the digital health design process. To address this, we conducted a qualitative study on how designers address digital PEx in design practice. The fourth direction is to standardize evaluation indicators, methods, or tools for assessing digital PEx; we are currently evaluating digital PEx in a parallel study. The fifth direction is to quantify the balance between the benefits and costs of developing user-friendly and validated DHIs. The sixth direction is to identify participants’ reasons for dropping out and their impact on the reported digital PEx–related results.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>To the best of our knowledge, this is the first study to propose the term “digital patient experience” as a common phrase to describe PEx in digital health and define digital PEx by synthesizing the reported PEx or UX of varied DHIs from multiple reviews. <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref> shows more details about the structure of this study. In this review, information on influencing factors was identified and summarized into 9 categories (ie, patient capability, opportunity, motivation, intervention technology, functionality, interaction design, organizational, physical environment, and social environment). These categories were classified into positive, negative, and double-edged factors based on their positive, negative, and diverse impacts on digital PEx. Our review uncovered 4 design constructs (personalized, information, navigation, and visual design) and 3 common design methods (UCD or HCD, co-design, and inclusive design) as design considerations for addressing digital PEx. Finally, we proposed a design and evaluation framework and design guidelines to help digital health designers and developers address digital PEx throughout the entire design process.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Study characteristics and digital health intervention characteristics of included reviews.</p>
        <media xlink:href="jmir_v24i8e37952_app1.docx" xlink:title="DOCX File , 48 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Influencing factors on digital patient experience (double-edged factors imply diverse impact, positive factors imply positive impact, and negative factors imply negative impact).</p>
        <media xlink:href="jmir_v24i8e37952_app2.docx" xlink:title="DOCX File , 29 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Detailed information on themes of influencing factors of the digital patient experience.</p>
        <media xlink:href="jmir_v24i8e37952_app3.docx" xlink:title="DOCX File , 36 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist.</p>
        <media xlink:href="jmir_v24i8e37952_app4.docx" xlink:title="DOCX File , 32 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">DHI</term>
          <def>
            <p>digital health intervention</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">HCD</term>
          <def>
            <p>human-centered design</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">HCP</term>
          <def>
            <p>health care provider</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">HIS</term>
          <def>
            <p>health information system</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">PEx</term>
          <def>
            <p>patient experience</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">PRISM</term>
          <def>
            <p>Performance of Routine Information System Management</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">UCD</term>
          <def>
            <p>user-centered design</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">UX</term>
          <def>
            <p>user experience</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This work was supported by the China Scholarship Council under grant 201906790084.</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>TW conceived, designed, and led the overall study, conducted data collection, led the data analysis and interpretation, and drafted the manuscript. TW and GG performed the review selection and data interpretation. GG, MM, and RG participated in the overall study; contributed to the analysis and interpretation of the study data; and conceptualized, reviewed, and suggested modifications regarding the presentation of results. All authors have read and approved the final manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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