<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Internet Res</journal-id><journal-id journal-id-type="publisher-id">jmir</journal-id><journal-id journal-id-type="index">1</journal-id><journal-title>Journal of Medical Internet Research</journal-title><abbrev-journal-title>J Med Internet Res</abbrev-journal-title><issn pub-type="epub">1438-8871</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v27i1e68269</article-id><article-id pub-id-type="doi">10.2196/68269</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter to the Editor</subject></subj-group></article-categories><title-group><article-title>Virtual Reality in Obesity Management: Addressing Key Limitations in Clinical Application</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Hu</surname><given-names>Xin</given-names></name><degrees>MM</degrees><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Wei</surname><given-names>Bin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University</institution><addr-line>17 Yongwai Zheng Street</addr-line><addr-line>Nanchang</addr-line><country>China</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Leung</surname><given-names>Tiffany</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Bin Wei, MD, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Zheng Street, Nanchang, 330000, China, 86 15072518856; <email>binw7119@126.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>27</day><month>6</month><year>2025</year></pub-date><volume>27</volume><elocation-id>e68269</elocation-id><history><date date-type="received"><day>01</day><month>11</month><year>2024</year></date><date date-type="accepted"><day>02</day><month>06</month><year>2025</year></date></history><copyright-statement>&#x00A9; Xin Hu, Bin Wei. Originally published in the Journal of Medical Internet Research (<ext-link ext-link-type="uri" xlink:href="https://www.jmir.org">https://www.jmir.org</ext-link>), 27.6.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.jmir.org/">https://www.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.jmir.org/2025/1/e68269"/><related-article related-article-type="commentary article" ext-link-type="doi" xlink:href="10.2196/51558" xlink:title="Comment on" xlink:type="simple">https://www.jmir.org/2024/1/e51558</related-article><kwd-group><kwd>obesity</kwd><kwd>virtual reality</kwd><kwd>psychological treatment</kwd><kwd>embodiment</kwd><kwd>motivational interviewing</kwd><kwd>self-conversation</kwd></kwd-group></article-meta></front><body><p>We are writing to express our appreciation for the recent publication in the <italic>Journal of Medical Internet Research</italic> titled &#x201C;Assessing the Clinical Efficacy of a Virtual Reality Tool for the Treatment of Obesity: Randomized Controlled Trial&#x201D; [<xref ref-type="bibr" rid="ref1">1</xref>]. The authors propose an innovative approach to obesity treatment that leverages the interactivity and immersive experience of virtual reality (VR) technology through a randomized controlled trial, providing new scientific evidence for obesity management. We commend the meticulous work and significant contributions of this study. However, while the randomized controlled design enhances the validity of these findings, there are several limitations worth further consideration.</p><p>First, in the VR experience, the system may not accurately simulate individual body types and postural characteristics, particularly for participants with significant body shape differences. This discrepancy can lead to a misalignment between the virtual representation and the participants&#x2019; self-perception, making it challenging for them to fully immerse themselves in their self-role or envisioned future selves. Furthermore, when individuals with obesity encounter substantial differences between their actual post&#x2013;weight loss appearance and their anticipated image through the VR experience, it may induce feelings of anxiety or depression, ultimately undermining their confidence in future weight management goals. Thus, this cognitive dissonance could diminish the positive impact of the intervention, hindering participants from achieving the desired behavioral and psychological transformations.</p><p>Second, the use of VR tools imposes a high technical proficiency requirement on participants. Although the study included participants with basic digital skills, individuals who are less familiar with digital technology, particularly older adults, rural residents, or those from cultural backgrounds with limited exposure to digital devices, may experience difficulties in adapting to and accepting VR equipment [<xref ref-type="bibr" rid="ref2">2</xref>]. This could lead to a dropout of potential participants due to technical barriers, ultimately affecting the actual effectiveness of the VR intervention. Future studies should consider incorporating adaptive training, technical support, and multicultural considerations to ensure the effectiveness and broader applicability of VR tools among diverse populations.</p><p>Moreover, while the article discusses the recruitment and randomization process of participants, it lacks detailed information on whether the sample represents the broader population of individuals with obesity [<xref ref-type="bibr" rid="ref3">3</xref>]. This may limit the generalizability of the findings. Additionally, although the study mentions short- and medium-term follow-ups, it does not address a long-term follow-up, which is essential for evaluating the sustainability of the intervention effects and whether participants can maintain the benefits of treatment over time.</p><p>In summary, VR holds promise as an important psychological intervention tool for treating obesity. The authors&#x2019; innovation and insights into VR treatment for obesity are commendable. However, these limitations may affect the interpretation and dissemination of the study results, emphasizing the need for caution when assessing the clinical efficacy of VR tools in obesity management.</p></body><back><ack><p>The authors used generative artificial intelligence (eg, ChatGPT) to assist with English language editing and refinement of this manuscript. All ideas, opinions, and final content are solely those of the authors.</p></ack><fn-group><fn fn-type="conflict"><p>None declared.</p></fn><fn fn-type="other"><p><bold>Editorial Notice</bold></p><p>The authors of &#x201C;Assessing the Clinical Efficacy of a Virtual Reality Tool for the Treatment of Obesity: Randomized Controlled Trial&#x201D; were invited to respond to this letter, but a response has not been provided at the time of publication.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">VR</term><def><p>virtual reality</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Anastasiadou</surname><given-names>D</given-names> </name><name name-style="western"><surname>Herrero</surname><given-names>P</given-names> </name><name name-style="western"><surname>Garcia-Royo</surname><given-names>P</given-names> </name><etal/></person-group><article-title>Assessing the clinical efficacy of a virtual reality tool for the treatment of obesity: randomized controlled trial</article-title><source>J Med Internet Res</source><year>2024</year><month>04</month><day>5</day><volume>26</volume><fpage>e51558</fpage><pub-id pub-id-type="doi">10.2196/51558</pub-id><pub-id pub-id-type="medline">38578667</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mergen</surname><given-names>M</given-names> </name><name name-style="western"><surname>Graf</surname><given-names>N</given-names> </name><name name-style="western"><surname>Meyerheim</surname><given-names>M</given-names> </name></person-group><article-title>Reviewing the current state of virtual reality integration in medical education - a scoping review</article-title><source>BMC Med Educ</source><year>2024</year><month>07</month><day>23</day><volume>24</volume><issue>1</issue><fpage>788</fpage><pub-id pub-id-type="doi">10.1186/s12909-024-05777-5</pub-id><pub-id pub-id-type="medline">39044186</pub-id></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Rudolph</surname><given-names>JE</given-names> </name><name name-style="western"><surname>Zhong</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Duggal</surname><given-names>P</given-names> </name><name name-style="western"><surname>Mehta</surname><given-names>SH</given-names> </name><name name-style="western"><surname>Lau</surname><given-names>B</given-names> </name></person-group><article-title>Defining representativeness of study samples in medical and population health research</article-title><source>BMJ Med</source><year>2023</year><month>05</month><day>16</day><volume>2</volume><issue>1</issue><fpage>e000399</fpage><pub-id pub-id-type="doi">10.1136/bmjmed-2022-000399</pub-id><pub-id pub-id-type="medline">37215072</pub-id></nlm-citation></ref></ref-list></back></article>