| EXECUTIVE PRESENTATION
Global Solutions for
Life Sciences
© Integromics, 2006. All Rights
Reserved
About Integromics
Integromics provides IT solutions in Life Sciences
(Genomics and Proteomics) for:
Data management and Integration
Intelligent data analysis and Data Mining
With two key partnerships:
© Integromics, 2006. All Rights
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Business Strategy
Products
• Proprietary Developments
• Development and Marketing of collaborative products
with Applied Biosystems Molecular Biology
• Development of integrated products with Spotfire
Technological platform
• Co-Selling of Spotfire & Integromics solutions
Services
• Professional services
• Microarrays Analysis
• Training
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Beyond Instrumentation and Reagents
Wet laboratory
Samples Experiments
Instruments Reagents
Life Science LIMS Data
Data management
Dry laboratory
Information
External data Data Analysis & Mining
New knowledge In silico laboratory/biology
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How Microarrays work (1)
1. Obtain the Microarray
2. Obtain two samples of specific cells: treat one
sample with a drug
3. From each sample collect messenger mRNA
4. Transcribe the mRNA into cDNA
5. Add fluorescence label green (Cy3) to untreated cells
and red (Cy5) to treated cells
6. Apply the labeled cDNAs to the chip.
Binding means that the gene in the cell sample
was expressed or active.
7. Binding occurs when cDNA from a sample
finds its complementary sequence of bases on
the chip
© Integromics, 2006. All Rights From Scientific American Feb 2002
Reserved
How Microarrays work (2)
8. Put the chip in a scanner and calculate the ratio of red to green at
each spot to quantify any changes in gene activity induced by the
drug
9. Determine whether any genes responded strongly to the drug in
ways known to promote liver damage or compare overall
expression
From Scientific American Feb 2002
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How Microarrays work (3)
Biological question
Experimental design
Failed
Microarray experiment
Quality
Image analysis
Measurement Preprocessing
Normalization
Pass
Secondary Analysis
Estimation Testing Clustering Discrimination
Biological verification
© Integromics, 2006. All Rights
and interpretation
Reserved
Our solutions : All around the Microarray Experimental Cycle
Discovery of
relationships between
gene expression data
New experiment
and annotations.
Scientific literature analysis Data storage and
(summarization, ontology management of microarray
terms extraction). experiments.
SpotFire Integration Guide
DecisionSite
A complete Gene expression Software solution for
Affymetrix, Agilent and others Microarray Platforms Data quality assessment (normalization,
quality enhancement, differential
expression) of gene expression data.
DecisionSite
A complete Gene expression Software solution for
Applied Biosystems 1700© MicroarrayPlatform
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| Our Knowledge : Data Analysis & Biological Interpretations
Powerful Text Mining Tool Strong tool for association
to extract biological rule discovery in gene
Knowledge from Scientific expression and
Documents annotations
Key Features:
- Microarray Quality Control.
- Gene Filtering, Normalization.
He at Map
Control_1
Control_2
Control_3
Integromics Gene expression
Me zc la _1
- Differential Expression.
Me zc la _2
Me zc la _3
T uni_1
T uni_2
T uni_3
Software solution for Affymetrix, Agilent - Annotations.
Xox_1
Xox_2
Xox_3
AB1700 and others Microarray Platforms - TLDA Analysis.
Microarray Platforms Taqman Low-Density Arrays
Data Management LIMS Functional Interpretation
| Sales & Marketing : International Customers
Worldwide HOT Spots :
MedBiogene
Human workflows (US reseller)
NIH
New-york
National Cancer
Institute (15 entities) Louisiana
University
Pfizer UK
Pfizer France
UCB Pharma
French independent IMGM
reseller Biogemma
ETH Zurich Institute
Ouest Genopole MEDUNI GATZ Institute
Genescore
Genome Novartis ST Microelectronics
PCM express Roche
Progenika
National Cancer Research King Faisal hospital
CNIC
Institute
CBM San Pau Hospital Naples (Saudi arabia)
university
Cibasa
| Integromics Offices / Contact
Parque Cientifico de Madrid
Direction & Sales
Campus de la Salud de Granada (R&D)
R&D, Presales, Support
Ruse - Bulgaria (Developments)
Technical Development team
Contact : Dr. Olivier Brun, General Manager
Tel: +34 685 153 813; Email: [Link]@[Link]
or Visit our website at [Link]
© Integromics, 2006. All Rights
Reserved
