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║               E  N  T  R  O  P  Y     E  D  I  T  I  O  N  ║
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║        🧘 Biofeedback-Driven Chair Yoga for Every  🧘    ║
║                   Apple Platform                         ║
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✨ Guided wellness sessions with real-time heart rate, Shannon Collapse Index, adaptive music, CareKit prescriptions, and multi-screen display across iPhone, iPad, Apple Watch, Apple TV, and Apple Vision Pro. ✨

Swift iOS watchOS visionOS tvOS License

Docking Poses Yoga Poses Types Plans Biofeedback CareKit CloudKit Zero deps

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           NATURaL RPG                 TRAINER CARD
   ╔════════════════════════╗    ╔═══════════════════════╗
   ║  Press START to begin  ║    ║ NAME: Bonhomme        ║
   ║                        ║    ║ REGION: Apple          ║
   ║   ◄ NEW GAME ►        ║    ║ BADGES: 13             ║
   ║     CONTINUE           ║    ║ YOGA: 26/26            ║
   ║     OPTIONS            ║    ║ POKEDRUG: 84/84        ║
   ╚════════════════════════╝    ╚═══════════════════════╝

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📖 Codex Entry #001 — Overview

┌─────────────────────────────────────────────────────┐
│  #001  NATURaL                                      │
│  Code Name: Bonhomme                                │
│  Type: BIOFEEDBACK / ENTROPY                        │
│  Region: All Apple Platforms                        │
│                                                     │
│  "A chair yoga app that pairs guided poses with     │
│   live biofeedback from Apple Watch. Sessions       │
│   render simultaneously on phone, TV, and Vision    │
│   Pro through a unified display architecture."      │
│                                                     │
│  STATS          ░░░░░░░░░░░░░░░░░░░░                │
│  HP ████████████████████░░░  85/100                  │
│  ATK ██████████████░░░░░░░  65/100  (Entropy)       │
│  DEF ████████████████████░  90/100  (Stability)     │
│  SPD ██████████████████░░░  80/100  (Real-time)     │
│  SP  █████████████████████  95/100  (Multi-signal)  │
└─────────────────────────────────────────────────────┘

The Shannon Collapse Index (SCI) — inspired by the entropy framework in Shannon and the thermodynamic scoring validated in FlexAID∆S — measures focus coherence from heart rate variability in real time. When HRV entropy narrows during deep breathing, the SCI rises, giving practitioners a live "focus ring" on every display surface.

Normal resting HRV:    H ~ 6-8 bits   (broad, variable intervals)
Focused breathing:     H ~ 2-4 bits   (narrow, coherent rhythm)
                       ─────────────────────────────────────────
SCI score:             0 ──────────── 50 ──────────── 100
                       😵 Distracted   😌 Settling    🧘 Deep Focus

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⚔️ Moves & Abilities

✨ NATURaL acquired the following skills! ✨

🟢 MOVE 1 — Pose Engine NORMAL

💪 Power26 poses / 3 levels
🎯 AccuracyBilingual EN + FR-CA
🔋 PPUnlimited
  • 🧘 26 chair yoga poses across 3 difficulty levels with bilingual content (English / French Canadian)
  • 🦴 7 anatomical categories: spine, hip, shoulder, neck, balance, breathing, full-body
  • ⚠️ Per-pose modifications, contraindications, and breathing patterns
  • 🗣️ Voice cue text for guided audio in both languages
  • 🎨 Category-specific SF Symbols and accent colors for visual differentiation

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🟣 MOVE 2 — Biofeedback Pipeline PSYCHIC

💪 PowerReal-time HRV
🎯 AccuracyShannon Entropy
🔋 PPContinuous
  • 💓 Real-time heart rate and calorie tracking via HKWorkoutSession
  • 📊 Shannon Collapse Index computed from R-R interval entropy via shared EntropyCalculator
  • 🔌 Generalized HealthSignalSignalAnalyzerFeedbackEngine architecture supporting unlimited signal types
  • 🔗 Cross-signal correlation (medication timing vs. HRV response)
  • 💚 HR zone classification with animated gauge (Recovery → Anaerobic)
  • ⭕ Activity ring integration (Move / Exercise / Stand)
  • 🏋️ Apple Fitness+ session history blended into unified timeline
  • 📡 Background delivery for HRV, sleep, respiratory rate, and medication records

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🐉 ABILITY — Multi-Signal Analysis Engine DRAGON

💥 Critical hit! The analysis pipeline is built on a protocol-driven architecture that generalizes the SCI methodology to any health signal:

HealthSignal (protocol)          SignalAnalyzer (protocol)
├── HRVSignal ──────────────────▸ HRVAnalyzer (Shannon entropy → SCI)
├── MedicationSignal ───────────▸ MedicationAnalyzer (adherence scoring)
├── DockingSignal ─────────────▸ DockingInsightAnalyzer (FlexAID∆S entropy)
└── SurveySignal ───────────────▸ (extensible for ResearchKit surveys)
                                         │
                                         ▼
                                   FeedbackEngine
                                   (orchestrator with cross-signal context)
                                         │
                                         ▼
                                   AnalysisInsight
                                   (score 0–1, trend, status, bilingual summary)

The EntropyCalculator — extracted as a shared utility — enables entropy-based scoring for any distribution: HRV intervals, sleep stage durations, respiratory rate patterns, or activity variability.

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☠️ MOVE 3 — Drug Response Analysis (PokeDrug) POISON

💪 Power70+ pharmacokinetic profiles
🎯 Accuracyp < 0.05 validated
🔋 PPPer-dose event

Detects autonomic drug response signatures by measuring Shannon entropy changes in HRV RR-interval distributions around medication dose events — the physiological analog of FlexAID∆S molecular docking entropy:

🧪 FlexAID∆S (in silico)           💊 NATURaL (in vivo)
─────────────────────           ─────────────────────
Torsional angles (°)            RR intervals (ms)
H = -Σ p_i log₂(p_i)           H = -Σ p_i log₂(p_i)     ← same math
Binding → ΔS_config < 0        Drug → ΔH_hrv < 0         ← same signal
                    ↘                     ↙
                  🔬 EntropyCalculator (shared)
  • 📈 DrugResponseAnalyzer — Computes baseline entropy (30 min pre-dose), measures ΔH at post-dose windows (15–360 min), detects entropy collapse (sympathomimetic) or expansion (parasympathomimetic)
  • 💊 70+ pharmacokinetic profiles — Substance database with autonomic mechanism, Tmax, expected ΔH range, therapeutic class, and FDA status
  • 🧬 60+ binding entropy profiles — Published ΔS_config values (bits) and -TΔS (kcal/mol) from computational chemistry literature
  • 🔬 CrossDomainValidator — Correlates |ΔS_config| (molecular) with |ΔH_hrv| (physiological) via Pearson r to validate the entropy-collapse framework across domains
  • 🔩 FlexAIDdSAnalyzer — Computes configurational entropy from torsional angle distributions using the same EntropyCalculator
  • 📋 MedicationTracker — HealthKit FHIR medication import, manual dose logging, automatic drug response analysis

📄 See POKEDRUG_PLAN.md for the complete technical plan.

☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️

🧚 MOVE 4 — Adaptive MusicKit FAIRY

💪 PowerSCI-driven
🎯 Accuracy3s crossfade
🔋 PPPer-session

🎵 Music dynamically adjusts based on real-time SCI during workouts:

  • 🚀 High coherence + improving (SCI > 70%): crossfade to energizing playlists
  • 🧘 Low coherence (SCI < 30%): fade to meditative/calming tracks
  • ⚖️ Mid-range: maintain current mood
  • ⏱️ 30-second debounce prevents jarring rapid transitions
  • 🎚️ 3-second volume crossfade between mood switches

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🏥 MOVE 5 — CareKit Integration STEEL

💪 PowerClinical-grade
🎯 AccuracyOCKStore
🔋 PPPrescribed

For clinical and rehabilitation settings where a therapist prescribes yoga regimens:

  • 🏗️ CareKitBridge manages OCKStore with prescribed task scheduling
  • 📝 YogaTaskBuilder maps WorkoutPlan to OCKTask with frequency-based scheduling
  • ✅ Workout completions automatically recorded as OCKOutcome with duration, calories, SCI score
  • 📊 Adherence tracking over configurable time windows
  • 💊 "Prescribed" section in HomeView when active prescriptions exist

⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️⚙️

👻 MOVE 6 — State Restoration GHOST

💪 PowerSeamless
🎯 Accuracy5s intervals
🔋 PPAutomatic

If the app is killed mid-workout, the session resumes seamlessly:

  • 💾 WorkoutStateStore persists phase, pose index, and timing every 5 seconds
  • 🔄 On relaunch, the app detects persisted state and offers a resume prompt
  • ❤️‍🩹 HealthKit workout sessions recovered via HKWorkoutSession persistence (iOS 17+)
  • 🧹 State cleared on normal completion or explicit stop

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🧊 MOVE 7 — CloudKit Sync ICE

💪 PowerCross-device
🎯 AccuracySwiftData
🔋 PPAutomatic

☁️ Cross-device persistence with automatic iCloud synchronization:

  • 📓 WorkoutRecord — full workout history with SCI scores
  • 🔥 SessionStreak — daily practice streak tracking
  • ⚙️ UserPreferences — language, music mood, notification settings
  • 💊 MedicationSchedule — user-defined dose reminders
  • 📦 Shared app group container for widget data access
  • 🛟 Automatic fallback to local storage when iCloud unavailable

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🧠 MOVE 8 — Apple Intelligence PSYCHIC

💪 PowerOn-device AI
🎯 AccuracyFoundationModels
🔋 PPiOS 26+

🤖 On-device insight generation via the FoundationModels framework:

  • 💡 InsightEngine synthesizes natural-language narratives from multi-signal analysis
  • 🎯 Personalized pose coaching based on current biofeedback context
  • 📝 Post-workout summary generation correlating HRV, medication, and survey data
  • 🌐 Template-based bilingual fallback on pre-iOS 26 devices

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🦅 MOVE 9 — Multi-Screen Display FLYING

💪 Power5 surfaces
🎯 AccuracyBonjour + AirPlay
🔋 PPSimultaneous
  • 📺 Native tvOS companion via Bonjour (_bonhomme._tcp) with length-prefixed JSON framing
  • 🖥️ AirPlay 2 second-screen via UIScene with .windowExternalDisplayNonInteractive role
  • 🔄 Automatic fallback: tvOS discovery (3s timeout) → AirPlay route detection
  • 🎨 Shared TVDisplayView rendered identically on both paths
                                       ┌──────────────────┐
              ┌───── NWConnection ────▸ │  📺 tvOS         │
              │                        │  TVDisplayView    │
┌─────────────┤                        └──────────────────┘
│  📱 iPhone  │
│  (iOS 17+)  │                        ┌──────────────────┐
│             ├───── AVRouteDetect ───▸ │  🖥️ AirPlay 2    │
│  🏋️ Workout │                        │  Second Screen    │
│  Engine     │                        └──────────────────┘
│             │
│  📊 Feedback│                        ┌──────────────────┐
│  Engine+SCI ├───── WCSession ───────▸ │  ⌚ Apple Watch   │
│             │      (biofeedback)     │  Native HKSession│
│  🎵 Adaptive│                        │  On-wrist SCI    │
│  MusicKit   │                        └──────────────────┘
│             │
│  🏥 CareKit│                        ┌──────────────────┐
│  Bridge     ├───── SwiftUI ─────────▸ │  📱 iPad         │
│             │      (NavigationSplit)  │  60/40 Split     │
│  💾 SwiftDat│                        └──────────────────┘
│  + CloudKit │
└─────────────┤                        ┌──────────────────┐
              └───── RealityKit ──────▸ │  🥽 Vision Pro   │
                                       │  Immersive Space │
                                       │  3D Pose Figure  │
                                       └──────────────────┘

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🎖️ Party Roster — Platform Integration

🎮 Your party is ready for battle! 🎮

Feature Framework Platform
🏃 Workout recording HealthKit (HKWorkoutSession) iOS / watchOS
💓 Heart rate monitoring HealthKit (HKAnchoredObjectQuery) iOS / watchOS
📊 On-wrist SCI computation FeedbackEngine + HRVAnalyzer watchOS
📡 Watch ↔ Phone relay WatchConnectivity (WCSession) watchOS / iOS
🏋️ Fitness+ history HealthKit (source bundle filter) iOS
Activity rings HealthKit (HKActivitySummary) iOS
📥 Background delivery HealthKit (enableBackgroundDelivery) iOS
💊 Medication records HealthKit (FHIR clinical records) iOS
🧘 Mindful session write HealthKit (HKCategoryType.mindfulSession) iOS
📳 Live Activities ActivityKit iOS
📊 Home & Lock Screen widgets WidgetKit iOS
🗣️ Siri shortcuts App Intents (4 intents + 2 entities) iOS
🎵 Adaptive music MusicKit (SCI-driven crossfade) iOS
👥 Group sessions SharePlay (GroupActivity) iOS
💰 Subscriptions StoreKit 2 iOS
🏥 Care plan prescriptions CareKitStore (OCKStore) iOS
💾 Data persistence + sync SwiftData + CloudKit iOS
🤖 On-device AI insights FoundationModels (iOS 26+) iOS
📱 iPad multicolumn NavigationSplitView iPadOS
🥽 Spatial display RealityKit + ImmersiveSpace visionOS

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🧘 Chair Yoga — Workout Plans

🎮 Select your training regimen! 🎮

Plan Poses Duration Level Access
🌅 Morning Flow 5 ~4 min 🟢 Beginner 🆓 Free
🌸 Gentle Stretch 5 ~4 min 🟢 Beginner 🆓 Free
💼 Quick Desk Break 5 ~3 min 🟢 Beginner 🆓 Free
🧘 Full Session 8 ~7 min 🟡 Mixed ⭐ Premium
💪 Strength & Balance 6 ~5 min 🟡 Intermediate ⭐ Premium
🔥 Advanced Chair Yoga 8 ~6 min 🔴 Advanced ⭐ Premium

26 bilingual chair yoga poses (EN/FR-CA) across 3 difficulty tiers — see MOVE 1 above.

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🧬 PokeDrug TYPE Chart

⚡ Every substance has a TYPE. Every TYPE has a signature. ⚡

A Pose in PokeDrug is not a yoga posture — it's a molecular docking pose: a drug (ligand) bound to its receptor (target) in a specific binding geometry. Each pose has a conformational entropy cost (ΔS_config) measured in bits, and a detectable autonomic signature measured via Apple Watch HRV.

FIRE ICE DRAGON GHOST ELECTRIC

POISON FAIRY PSYCHIC GRASS STEEL

🎯 TYPE → Signal Detection

Each TYPE maps to a real physiological event detected through HealthKit or molecular docking:

TYPE Pharmacological Basis HealthKit / Docking Signal
🔥 FIRE Stimulates fight-or-flight (amphetamine, cocaine, caffeine) HR ↑, HRV entropy collapse (ΔH < 0)
🧊 ICE Calms autonomic system (beta-blockers, clonidine) HR ↓, HRV entropy expansion (ΔH > 0)
🐉 DRAGON Dual-branch / biphasic (antipsychotics, alcohol) Biphasic ΔH — initial collapse then expansion
👻 GHOST Enhances GABA inhibition (benzodiazepines, zolpidem) Respiratory rate ↓, sleep entropy shift
ELECTRIC Targets reward pathway (bupropion, modafinil) Activity ring spike, acute HRV compression → rebound
☠️ POISON Blocks acetylcholine (atropine, scopolamine) Vagal brake removed → paradoxical sympathetic ↑
🧚 FAIRY Modulates 5-HT receptors (SSRIs, psychedelics) Slow HRV modulation over days, sleep architecture Δ
🔮 PSYCHIC Binds μ/κ/δ opioid receptors (morphine, fentanyl) Deep parasympathetic shift, respiratory entropy collapse
🌿 GRASS CB1/CB2 agonism (THC, CBD) Mixed HR response, altered HRV spectral balance
⚙️ STEEL Rigid molecules / structural agents (lithium, lamotrigine) Minimal ΔS_config, subtle ΔH_hrv

⚔️ TYPE Effectiveness — Cross-Signal Interactions

💥 When two TYPEs collide, the entropy tells the story! 💥

Matchup Interaction Entropy Signature
🔥 FIRE vs 🧊 ICE Sympathomimetic + beta-blocker Mutual cancellation — ΔH → 0
👻 GHOST vs ⚡ ELECTRIC Sedative dampens stimulant rebound Entropy stays collapsed longer
☠️ POISON vs 🧚 FAIRY Anticholinergic blocks serotonergic GI Blunted ΔH time-course
🔮 PSYCHIC vs 🔥 FIRE Opioid + stimulant (speedball) Dangerous mixed signal — chaotic ΔH
🐉 DRAGON vs any Mixed agents resist classification Biphasic ΔH curves, type-resistant
🌿 GRASS vs 👻 GHOST Cannabinoid + GABAergic Additive sedation, entropy expansion
⚙️ STEEL vs all Rigid molecules bind cleanly Minimal conformational penalty (low
Code mapping (PharmacokineticProfile.swift):

AutonomicMechanism.sympathomimetic  ──→  🔥 FIRE
AutonomicMechanism.parasympathomimetic ──→  🧊 ICE
AutonomicMechanism.mixed            ──→  🐉 DRAGON
TherapeuticClass.anxiolytic/.sedativeHypnotic ──→  👻 GHOST
TherapeuticClass.stimulant (NDRI)   ──→  ⚡ ELECTRIC
TherapeuticClass.anticholinergic    ──→  ☠️ POISON
TherapeuticClass.antidepressant (SSRI/SNRI) ──→  🧚 FAIRY
TherapeuticClass.opioidAnalgesic    ──→  🔮 PSYCHIC
TherapeuticClass.cannabinoid        ──→  🌿 GRASS
(rigid molecules, |ΔS| < 2 bits)   ──→  ⚙️ STEEL

🔥🧊🐉👻⚡☠️🧚🔮🌿⚙️🔥🧊🐉👻⚡☠️🧚🔮🌿⚙️🔥🧊🐉👻⚡☠️🧚🔮🌿⚙️🔥🧊🐉👻⚡☠️🧚🔮🌿⚙️

🧬 PokeDrug Codex — Docking Poses

🎯 Gotta dock 'em all! 🎯

🎲 Flexibility Distribution

| Tier | Rotatable Bonds | |ΔS_config| | Docking Difficulty | |------|----------------|------------|-------------------| | 🟢 Rigid | 0–2 | < 3 bits | Easy — molecule snaps into pocket | | 🟡 Flexible | 3–5 | 3–8 bits | Medium — conformational search needed | | 🔴 Highly Flexible | 6+ | > 8 bits | Hard — massive entropy penalty on binding |

🔥 FIRE — Sympathomimetics (click to expand)

Stimulates fight-or-flight via catecholamine release or reuptake inhibition. Detected by HR ↑ and HRV entropy collapse (ΔH < 0).

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
1 amphetamine Stimulant (DAT/NET) 2 -2.9 1.2 3h 10h -2.0 to -0.8 C-II 🟢
2 dextroamphetamine Stimulant (DAT/NET) 2 -2.9 1.2 3h 12h -2.0 to -0.8 C-II 🟢
3 methamphetamine Stimulant (DAT/NET) 2 -3.2 1.3 3h 10h -2.5 to -1.0 C-II 🟡
4 lisdexamfetamine Prodrug → d-amph 4 -4.4 1.8 3.5h 12h -1.8 to -0.6 C-II 🟡
5 methylphenidate Stimulant (DAT) 3 -6.8 2.8 2h 3h -1.5 to -0.5 C-II 🟡
6 cocaine DAT/NET/SERT blocker 4 -4.9 2.0 30m 1h -2.5 to -1.0 C-II 🟡
7 caffeine Xanthine (A₂ₐ antag) 0 -1.0 0.4 45m 5h -0.8 to -0.2 🟢
8 theophylline Xanthine (PDE inhib) 0 -0.7 0.3 1.5h 8h -0.6 to -0.1 Rx 🟢
9 nicotine nAChR agonist 1 -2.2 0.9 10m 2h -1.0 to -0.3 🟢
10 mdma Monoamine releaser 3 -3.7 1.5 2h 8h -1.8 to -0.5 C-I 🟡
⚡ ELECTRIC — Dopaminergic / Noradrenergic (click to expand)

Targets the reward pathway via dopamine/norepinephrine reuptake inhibition or MAO inhibition. Detected by activity ring spike, acute HRV compression → rebound.

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
11 modafinil Wakefulness (DAT) 4 -5.3 2.2 3h 15h -0.8 to -0.2 C-IV 🟡
12 armodafinil Wakefulness (R-mod) 4 -5.3 2.2 2h 15h -0.8 to -0.2 C-IV 🟡
13 atomoxetine NRI (non-stimulant) 4 -6.1 2.5 1.5h 5h -1.0 to -0.3 Rx 🟡
14 bupropion NDRI 3 -4.4 1.8 2h 21h -0.8 to -0.2 Rx 🟡
15 phenelzine MAOI (irreversible) 2 -2.4 1.0 2h 12h -0.6 to 0.0 Rx 🟢
16 tranylcypromine MAOI (irreversible) 0 -1.2 0.5 1.5h 2.5h -1.0 to -0.3 Rx 🟢
🧊 ICE — Parasympathomimetics (click to expand)

Calms the autonomic system via β-adrenergic blockade or α₂-agonism. Detected by HR ↓ and HRV entropy expansion (ΔH > 0).

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
17 propranolol β-blocker (non-sel) 5 -8.5 3.5 1.5h 4h +0.3 to +1.5 Rx 🟡
18 metoprolol β₁-blocker (sel) 7 -9.7 4.0 1.5h 4h +0.2 to +1.2 Rx 🔴
19 atenolol β₁-blocker (hydro) 6 -9.3 3.8 3h 7h +0.2 to +1.0 Rx 🔴
20 bisoprolol β₁-blocker (hi-sel) 7 -9.7 4.0 2h 11h +0.2 to +1.0 Rx 🔴
21 carvedilol β+α₁-blocker 6 -8.5 3.5 1.5h 7h +0.2 to +1.3 Rx 🔴
22 clonidine α₂-agonist (central) 1 -1.5 0.6 2h 12h +0.3 to +1.5 Rx 🟢
23 guanfacine α₂A-agonist (sel) 2 -3.4 1.4 4h 17h +0.2 to +1.2 Rx 🟡
24 digoxin Cardiac glycoside 8 -12.2 5.0 2h 42h +0.2 to +0.8 Rx 🔴
25 ivabradine If-channel blocker 5 -7.3 3.0 1h 6h -0.2 to +0.3 Rx 🟡
🧚 FAIRY — Serotonergic (click to expand)

Modulates 5-HT receptors via reuptake inhibition (SSRIs/SNRIs), partial agonism, or direct agonism (psychedelics). Detected by slow HRV modulation over days and sleep architecture Δ.

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
26 sertraline SSRI 3 -5.4 2.2 6.5h 26h -0.5 to +0.1 Rx 🟡
27 fluoxetine SSRI 5 -7.3 3.0 7h 48h -0.5 to +0.1 Rx 🟡
28 escitalopram SSRI 4 -6.1 2.5 5h 30h -0.4 to +0.1 Rx 🟡
29 paroxetine SSRI + ACh 3 -4.9 2.0 5h 21h -0.6 to 0.0 Rx 🟡
30 venlafaxine SNRI 6 -9.3 3.8 2h 5h -0.8 to -0.1 Rx 🔴
31 duloxetine SNRI 3 -5.6 2.3 6h 12h -0.7 to -0.1 Rx 🟡
32 trazodone SARI 4 -6.8 2.8 1h 7h 0.0 to +0.5 Rx 🟡
33 buspirone 5-HT₁A agonist 5 -7.3 3.0 1h 2.5h -0.2 to +0.3 Rx 🟡
34 psilocybin 5-HT₂A agonist 3 -3.4 1.4 1.5h 3h -0.6 to +0.3 C-I 🟡
35 lsd 5-HT₂A agonist 1 -2.4 1.0 2h 3.5h -0.5 to +0.2 C-I 🟢
🐉 DRAGON — Mixed / Biphasic (click to expand)

Dual-branch autonomic agents (antipsychotics, alcohol) with multi-receptor affinity. Detected by biphasic ΔH — initial collapse then expansion.

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
36 quetiapine Atypical AP (D₂/5-HT₂) 7 -11.0 4.5 1.5h 7h -0.3 to +0.4 Rx 🔴
37 olanzapine Atypical AP (D₂/5-HT₂) 2 -4.4 1.8 6.5h 30h -0.5 to +0.2 Rx 🟡
38 risperidone Atypical AP (D₂/5-HT₂) 4 -6.8 2.8 1h 21h -0.4 to +0.2 Rx 🟡
39 haloperidol Typical AP (D₂) 6 -8.8 3.6 4h 24h -0.4 to +0.1 Rx 🔴
40 chlorpromazine Typical AP (D₂/ACh) 3 -4.9 2.0 3h 30h -0.5 to +0.2 Rx 🟡
41 clozapine Atypical AP (multi) 2 -3.7 1.5 2.5h 12h -0.6 to +0.1 Rx 🟡
42 aripiprazole AP (D₂ partial ag) 6 -8.5 3.5 4h 75h -0.3 to +0.2 Rx 🔴
43 ethanol GABA-A / NMDA 0 -0.2 0.1 1h 1.5h -1.0 to +0.5 🟢
44 mirtazapine NaSSA (α₂/5-HT₂/H₁) 1 -2.9 1.2 2h 30h +0.1 to +0.6 Rx 🟢
45 hydroxyzine Antihistamine (H₁) 5 -7.8 3.2 2h 20h 0.0 to +0.5 Rx 🟡
👻 GHOST — GABAergic / Sedative (click to expand)

Enhances GABA-A inhibition (benzodiazepines), blocks orexin (suvorexant), or activates GABA-B (GHB). Detected by respiratory rate ↓ and sleep entropy shift.

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
46 alprazolam BZD (short-acting) 0 -2.0 0.8 1.5h 11h +0.2 to +1.0 C-IV 🟢
47 diazepam BZD (long-acting) 1 -2.7 1.1 1.25h 60h +0.2 to +1.0 C-IV 🟢
48 lorazepam BZD (intermediate) 0 -2.2 0.9 2h 12h +0.2 to +0.9 C-IV 🟢
49 clonazepam BZD (long-acting) 0 -2.2 0.9 2.5h 35h +0.2 to +0.9 C-IV 🟢
50 zolpidem Z-drug (ω₁ sel) 2 -3.4 1.4 1.6h 2.5h +0.1 to +0.6 C-IV 🟡
51 suvorexant Orexin antagonist 4 -6.1 2.5 2h 12h 0.0 to +0.4 C-IV 🟡
52 ghb GABA-B agonist 2 -1.5 0.6 35m 45m +0.2 to +1.0 C-I/III 🟢
🔮 PSYCHIC — Opioidergic (click to expand)

Binds μ/κ/δ opioid receptors as full agonists, partial agonists, or antagonists. Detected by deep parasympathetic shift and respiratory entropy collapse.

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
53 morphine μ-agonist (full) 1 -2.4 1.0 1h 2.5h +0.2 to +1.2 C-II 🟢
54 oxycodone μ-agonist (full) 1 -2.9 1.2 1.5h 3.5h +0.2 to +1.2 C-II 🟢
55 hydrocodone μ-agonist (full) 1 -2.7 1.1 1.3h 4h +0.2 to +1.0 C-II 🟢
56 fentanyl μ-agonist (potent) 7 -10.2 4.2 25m 7h +0.3 to +1.5 C-II 🔴
57 methadone μ-agonist (long) 5 -7.8 3.2 3.25h 30h +0.2 to +1.0 C-II 🟡
58 buprenorphine μ-partial agonist 2 -3.7 1.5 1h 37h +0.1 to +0.7 C-III 🟡
59 tramadol μ-weak + SNRI 3 -4.9 2.0 2h 6h -0.2 to +0.6 C-IV 🟡
60 naltrexone μ-antagonist 2 -3.2 1.3 1h 4h -0.4 to +0.1 Rx 🟢
☠️ POISON — Anticholinergic (click to expand)

Blocks muscarinic acetylcholine receptors, removing the vagal brake. Detected by paradoxical sympathetic ↑ (HR rises despite no catecholamine release).

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
61 atropine mAChR antagonist 4 -7.8 3.2 1h 4h -1.2 to -0.4 Rx 🟡
62 scopolamine mAChR antagonist 4 -6.8 2.8 1h 4.5h -0.6 to 0.0 Rx 🟡
63 diphenhydramine H₁-antag + mAChR 4 -6.8 2.8 2h 6h -0.4 to +0.2 OTC 🟡
64 promethazine H₁-antag + mAChR 3 -5.3 2.2 2.5h 12h -0.3 to +0.3 Rx 🟡
🌿 GRASS — Cannabinoid (click to expand)

CB1/CB2 receptor agonism with mixed autonomic effects. Detected by mixed HR response and altered HRV spectral balance (LF/HF ratio shift).

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
65 thc CB1/CB2 agonist 4 -5.3 2.2 10m (inh) 30h -0.8 to +0.3 C-I 🟡
66 dronabinol Synthetic THC 4 -5.3 2.2 3h (oral) 30h -0.6 to +0.3 C-III 🟡
⚙️ STEEL — Structural / Rigid Agents (click to expand)

Rigid molecules that bind cleanly with minimal conformational penalty (low |ΔS|). Includes mood stabilizers, anticonvulsants, NSAIDs, corticosteroids, muscle relaxants, and TCAs.

# Substance Class Bonds ΔS (bits) -TΔS Tmax ΔH_hrv (bits) Schedule Tier
67 lithium Mood stab (monatomic) 0 0.0 0.0 3h 27h -0.3 to +0.2 Rx 🟢
68 gabapentin Ca²⁺-channel ligand 3 -3.7 1.5 2.5h 6h 0.0 to +0.5 Rx 🟡
69 pregabalin Ca²⁺-channel ligand 3 -3.9 1.6 1.5h 6h 0.0 to +0.5 C-V 🟡
70 lamotrigine Na⁺-channel blocker 1 -1.7 0.7 2.5h 25h -0.2 to +0.2 Rx 🟢
71 valproate GABA enhancer (multi) 4 -4.4 1.8 4h 12.5h -0.2 to +0.3 Rx 🟡
72 carbamazepine Na⁺-channel blocker 1 -2.0 0.8 4.5h 14.5h -0.3 to +0.1 Rx 🟢
73 topiramate Multi-mechanism AED 3 -3.9 1.6 2h 21h -0.2 to +0.2 Rx 🟡
74 ibuprofen NSAID (COX inhib) 3 -3.9 1.6 1.5h 2h -0.2 to +0.2 OTC 🟡
75 prednisone Corticosteroid 2 -2.9 1.2 2h 3.5h -0.5 to 0.0 Rx 🟢
76 dexamethasone Corticosteroid (potent) 3 -3.7 1.5 2h 45h -0.5 to 0.0 Rx 🟡
77 metoclopramide D₂ antagonist (prokinetic) 4 -6.1 2.5 1.5h 5.5h -0.2 to +0.2 Rx 🟡
78 levothyroxine Thyroid hormone (T₄) 4 -5.9 2.4 3h 7d -0.3 to +0.1 Rx 🟡
79 cyclobenzaprine Muscle relax (TCA-like) 2 -3.7 1.5 5.5h 18h -0.4 to +0.1 Rx 🟡
80 baclofen GABA-B agonist 2 -2.9 1.2 2.5h 3.5h 0.0 to +0.4 Rx 🟢
81 tizanidine α₂-agonist (central) 1 -1.7 0.7 1h 2.5h +0.2 to +0.8 Rx 🟢
82 ketamine NMDA antagonist 1 -2.0 0.8 20m 2.5h -0.8 to +0.4 C-III 🟢
83 amitriptyline TCA (NE/5-HT + ACh) 3 -4.9 2.0 4h 25h -0.8 to -0.2 Rx 🟡
84 nortriptyline TCA (NE > 5-HT) 2 -3.9 1.6 5h 28h -0.7 to -0.1 Rx 🟡

84 docking poses catalogued · 10 pharmacological TYPEs · 3 flexibility tiers

🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣

🗺️ Region Map — Architecture

📦 Shared Swift Package

All models, analysis engine, and TV display views live in BonhommeCore, a platform-agnostic Swift Package compiled for iOS, watchOS, tvOS, and visionOS:

📦 BonhommeCore/
├── 📋 Package.swift                    # iOS 17, watchOS 10, tvOS 17, visionOS 1
└── 📂 Sources/BonhommeCore/
    ├── 🗂️ Models/
    │   ├── 🧘 Pose.swift               # Bilingual pose with category, difficulty, modifications
    │   ├── 📚 PoseCatalog.swift         # 26 poses + 6 workout plans
    │   ├── 🌐 LocalizedString.swift     # EN/FR-CA resolver by device locale
    │   ├── 📋 WorkoutPlan.swift         # Ordered pose sequence with computed duration
    │   ├── 📺 TVDisplayPayload.swift    # Codable message: iPhone → TV surface
    │   ├── 💓 BiofeedbackSnapshot.swift # HR, HRV, SCI, calories + multi-signal insights
    │   └── 📊 WorkoutResult.swift       # Post-session summary with HR samples
    ├── 🔬 Analysis/
    │   ├── 🧮 EntropyCalculator.swift   # Shared Shannon entropy utility (reusable)
    │   ├── 📡 HealthSignal.swift        # Protocol + HRVSignal, MedicationSignal, DockingSignal
    │   ├── 🔍 SignalAnalyzer.swift      # Protocol + AnalysisInsight, AnalysisContext
    │   ├── 💓 HRVAnalyzer.swift         # Shannon Collapse Index from R-R intervals
    │   ├── 💊 MedicationAnalyzer.swift  # Adherence scoring with HRV correlation
    │   ├── ⚙️ FeedbackEngine.swift      # Thread-safe multi-signal orchestrator
    │   ├── 📈 DrugResponseAnalyzer.swift # ΔH detection around medication dose events
    │   ├── 🧪 PharmacokineticProfile.swift # 70+ substance PK/autonomic profiles
    │   ├── 🧬 BindingEntropyProfile.swift # 60+ molecular ΔS_config reference values
    │   ├── 🔩 FlexAIDdSAnalyzer.swift   # Torsional ΔS_config computation
    │   ├── 🔬 CrossDomainValidator.swift # |ΔS_config| ↔ |ΔH_hrv| correlation
    │   └── 🔗 DockingInsightAnalyzer.swift # SignalAnalyzer adapter for FeedbackEngine
    └── 📺 TVDisplay/
        ├── 🖼️ TVDisplayView.swift       # Shared layout: 60% pose + 40% biofeedback
        ├── ⏱️ PoseCountdownView.swift   # Circular countdown timer with category color
        ├── 💚 HeartRateGaugeView.swift   # BPM gauge with HR zone
        ├── 🎯 SCIVisualizationView.swift # Focus ring with trend indicator
        └── 📊 SessionProgressView.swift  # Pose dots + elapsed time

🌐 Bilingual Data Model

Instead of .strings files, NATURaL uses a data-driven approach where all content is self-contained in the Swift Package:

public struct LocalizedString: Codable, Sendable, Hashable {
    public let en: String
    public let fr: String
    public var localized: String {
        Locale.current.language.languageCode?.identifier
            .hasPrefix("fr") == true ? fr : en
    }
}

🏗️ Repository Structure

🏠 NATURaL/
├── 📱 Bonhomme/                        # iOS app (iPhone + iPad hub)
│   ├── 🚀 App/                         # @main entry, AppState, SwiftData container
│   ├── ✨ Features/
│   │   ├── 🏋️ Workout/                 # Flow VM, guided session UI, home (iPad split)
│   │   ├── 📊 Summary/                 # Post-workout charts + SwiftData persistence
│   │   ├── 📜 History/                 # Blended NATURaL + Fitness+ timeline
│   │   └── 💰 Paywall/                 # StoreKit 2 subscription view
│   ├── ⚙️ Services/
│   │   ├── ❤️ HealthKit/               # HR, workout recorder, Fitness+ reader,
│   │   │                            # InsightEngine, MedicationTracker, ResearchKit
│   │   ├── 🎵 Music/                   # MusicKit adaptive playlists (SCI-driven)
│   │   ├── 💾 Persistence/             # WorkoutStateStore, SwiftData PersistentModels
│   │   ├── 🏥 CareKit/                 # CareKitBridge, YogaTaskBuilder
│   │   ├── ⌚ WatchConnectivity/       # PhoneConnectivityBridge (iOS ↔ Watch)
│   │   ├── 👥 SharePlay/               # GroupActivity session coordinator
│   │   ├── 🗣️ Siri/                    # App Intents + 4 shortcuts
│   │   └── 💳 Subscription/            # StoreKit 2 entitlements
│   ├── 📺 TVRelay/                     # Coordinator, AirPlay, native companion
│   └── 🎨 Shared/Components/           # Activity rings, reusable views
├── 📦 BonhommeCore/                    # Shared Swift Package (all platforms)
│   ├── 📂 Sources/BonhommeCore/        # Models + Analysis + TV display views
│   └── 🧪 Tests/BonhommeCoreTests/     # Unit tests (entropy, analyzers, codable)
├── 📺 BonhommeTV/                      # tvOS companion app
│   ├── 🚀 App/                         # @main entry
│   ├── 🌐 Networking/                  # NWListener Bonjour service
│   └── 🖼️ Views/                       # TV root + idle views
├── ⌚ BonhommeWatch/                   # watchOS companion app
│   └── 🚀 App/                         # WatchApp, WorkoutManager, WCSession bridge,
│                                    # SessionView (3-page vertical), HomeView
├── 🥽 BonhommeVision/                  # visionOS spatial app
│   └── 🚀 App/                         # VisionApp, SpatialPoseView, ImmersivePoseSpace,
│                                    # SpatialBiofeedbackView (ornament gauges)
├── 📳 NATURaLLiveActivity/             # ActivityKit Dynamic Island
├── 📊 NATURaLWidgets/                  # Streak + Activity Rings widgets
└── 🧪 Tests/
    ├── ✅ BonhommeTests/               # iOS app unit tests
    └── 🤖 BonhommeUITests/             # Xcode UI test suites

🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣

🔬 Professor's Lab — Build

📋 Requirements

Dependency Version
🛠️ Xcode 15.0+ (26+ for Apple Intelligence)
🦅 Swift 5.9+
📱 iOS deployment 17.0+
⌚ watchOS deployment 10.0+
📺 tvOS deployment 17.0+
🥽 visionOS deployment 1.0+
📦 External dependencies None (CareKit added at project level)

🚀 Quick Start

🧪 The Professor: "Are you ready? Your very own NATURaL adventure is about to unfold!" 🧪

# 📥 Clone
git clone https://github.com/lmorency/NATURaL.git
cd NATURaL

# 🛠️ Open in Xcode
open Bonhomme.xcodeproj    # or .xcworkspace

# 🎯 Select scheme → Bonhomme, destination → iPhone 15 Pro
# ⌘R to build and run

🎯 Targets

Scheme Destination Description
📱 Bonhomme iPhone / iPad Simulator (iOS 17+) Main hub app with adaptive layout
📺 BonhommeTV Apple TV 4K Simulator (tvOS 17+) TV companion display
⌚ BonhommeWatch Apple Watch Series 9 (watchOS 10+) Native HR sensor + on-wrist SCI
🥽 BonhommeVision Apple Vision Pro (visionOS 1.0+) Spatial yoga with 3D pose figure

🔐 Entitlements

Entitlement Purpose
❤️ HealthKit Workout recording, HR/HRV monitoring, medication records
🏥 HealthKit (clinical) FHIR medication record access
📡 Background Modes HealthKit background delivery, workout processing
☁️ iCloud (CloudKit) SwiftData cross-device sync
🤖 Apple Intelligence On-device Foundation Model insight generation

🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣

🏟️ Arena Challenge — Testing

🏆 "You've defeated the ARENA MASTER! You earned the test badge!" 🏆

# 🧪 BonhommeCore unit tests (platform-agnostic)
xcodebuild test -scheme BonhommeCore -destination 'platform=iOS Simulator,name=iPhone 15 Pro'

# 📱 iOS app unit tests
xcodebuild test -scheme Bonhomme -destination 'platform=iOS Simulator,name=iPhone 15 Pro'

# 🤖 UI tests (requires simulator)
xcodebuild test -scheme BonhommeUITests -destination 'platform=iOS Simulator,name=iPhone 15 Pro'

🏅 Arena Badges Earned

Badge Tests Scope
🟢 LocalizedStringTests 5 Codable, hashable, EN/FR resolution
🟢 PoseTests 5 Init, codable, difficulty/category enums
🟢 PoseCatalogTests 10 Unique IDs, bilingual coverage, distribution
🟢 WorkoutPlanTests 4 Duration calc, codable, edge cases
🟢 TVDisplayPayloadTests 4 Codable roundtrip, nil biofeedback, SCI trend
🟢 WorkoutResultTests 3 Result codable, nil heart rate
🟡 AnalyzerTests 17 Shannon entropy, SCI scoring, medication adherence, FeedbackEngine multi-signal, EntropyCalculator edge cases + parity
🟡 DrugResponseAnalyzerTests 24 Sympathomimetic/parasympathomimetic detection, dose-response curves, profile matching, batch aggregation, Cohen's d, AUC
🔴 FlexAIDdSAnalyzerTests 27 Torsional entropy, ΔS_config, kcal/mol conversion, cross-domain validation, BindingEntropyProfile registry, DockingInsightAnalyzer pipeline
🟢 WorkoutFlowViewModelTests 3 Plan structure, TV payload, localization
🟢 TVDisplayCoordinatorTests 3 Payload size <10KB, framing, Bonjour type
🟣 WorkoutFlowUITests 5 Home screen, navigation, countdown, a11y
🟣 AirPlayFallbackUITests 3 TV section, connection prompt, stability

🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅🏅

🌟 Legendary Allies — Related Projects

┌─────────────────────────────────────────────────────────┐
│  ✨ LEGENDARY ALLIES ENCOUNTERED! ✨                    │
│                                                         │
│  🔵 Shannon          — Entropy collapse detection.      │
│                        Provides the mathematical         │
│                        foundation for the SCI            │
│                        biofeedback metric.               │
│                                                         │
│  🔴 FlexAID∆S        — Entropy-driven molecular docking.│
│                        Validated the thermodynamic        │
│                        scoring framework adapted for      │
│                        HRV analysis.                     │
└─────────────────────────────────────────────────────────┘
Project Role
🔵 Shannon Entropy collapse detection — provides the mathematical foundation for the SCI biofeedback metric
🔴 FlexAID∆S Entropy-driven molecular docking — validated the thermodynamic scoring framework adapted for HRV analysis

🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣🔴🟠🟡🟢🔵🟣

🏆 Hall of Fame

╔══════════════════════════════════════════════════╗
║              🏆 HALL OF FAME 🏆                  ║
║                                                  ║
║  🔒 LICENSE: Proprietary. All rights reserved.   ║
║                                                  ║
║  🤝 CONTRIBUTING:                                ║
║  This project is currently in private            ║
║  development. Contact the maintainer for         ║
║  collaboration inquiries.                        ║
║                                                  ║
║        💾 SAVE GAME? [Y] / [N] 💾               ║
╚══════════════════════════════════════════════════╝

Gotta Dock 'Em All

About

Bonhomme— Fleeting— integration of Shannon Entropy Collapse into HealthKit, ResearchKit, CareKit, MusicKit, iOS, watchOS, tvOS, macOS, visionOS

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